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Selective COX-2 Inhibitors
The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are tw...
AI-ML for Decision and Risk Analysis
This book explains and illustrates recent developments and advances in decision-making and risk analysis. It demonstrates how artificial intelligence (AI) and machine learning (ML) have not only benefitted from classical decision analysis concepts such as expected utility maximization but have also contributed to making normative decision theory more useful by forcing it to confront realistic complexities. These include skill acquisition, uncertain and time-consuming implementation of intended actions, open-world uncertainties about what might happen next and what consequences actions can have, and learning to cope effectively with uncertain and changing environments. The result is a more robust and implementable technology for AI/ML-assisted decision-making. The book is intended to inform a wide audience in related applied areas and to provide a fun and stimulating resource for students, researchers, and academics in data science and AI-ML, decision analysis, and other closely linked academic fields. It will also appeal to managers, analysts, decision-makers, and policymakers in financial, health and safety, environmental, business, engineering, and security risk management.
Drug Discovery and Evaluation
This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.
Responsible Machine Learning
Like other powerful technologies, AI and machine learning present significant opportunities. To reap the full benefits of ML, organizations must also mitigate the considerable risks it presents. This report outlines a set of actionable best practices for people, processes, and technology that can enable organizations to innovate with ML in a responsible manner. Authors Patrick Hall, Navdeep Gill, and Ben Cox focus on the technical issues of ML as well as human-centered issues such as security, fairness, and privacy. The goal is to promote human safety in ML practices so that in the near future, there will be no need to differentiate between the general practice and the responsible practice o...
Davis
Charles Davies (b.ca. 1706) emigrated from England to Philadelphia, and married Hannah Matson in 1732/1733. Descendants (chiefly spelling the surname Davis) and relatives lived in Pennsylvania, North Carolina, Ohio, Indiana, Iowa, Nebraska, Kansas, Oklahoma, California and elsewhere.
U.S. Army Register
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