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The Golgi apparatus is a central organelle that lies at the heart of the secretory pathway. It ensures post-translational protein modifications such as glycosylation and cleavage as well as protein sorting to neuronal axons and dendrites. Structural and functional alterations of the Golgi apparatus (fragmentation and atrophy), which are collectively termed Golgi pathology, are now recognized as a constant feature of many neuro-degenerative diseases. However, the molecular mechanisms underlying these changes and their precise relevance to neurodegeneration have not yet been completely elucidated. This eBook contains 13 reviews that address the molecular mechanisms of Golgi pathology in Parkinson and Alzheimer diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophies, and discuss their potential relevance to the pathological loss of neuronal cell bodies, axons and synapses.
This book constitutes the refereed conference proceedings of the 9th International Conference on Advances in Computer Entertainment, ACE 2012, held in Kathmandu, Nepal, in November 2012. The 10 full paper and 19 short papers presented together with 5 papers from the special track Arts and Culture and 35 extended abstracts were carefully reviewed and selected from a total of 140 submissions in all categories. The papers cover topics across a wide spectrum of disciplines including computer science, design, arts, sociology, anthropology, psychology, and marketing. Focusing on all areas related to interactive entertainment they aim at stimulating discussion in the development of new and compelling entertainment computing and interactive art concepts and applications.
Cancer survivorship is a relatively new field in Oncology, although it's an increasingly important one. When it comes to breast cancer, as it has become a highly curable condition, survivorship is an up-to-date subject to be discussed by physicians and – why not? – by patients and their families. However, many books about cancer survivorship focus on general health issues and treatments' side effects, putting aside what patients should have known about it. Navigating breast cancer diagnosis, treatment and survivorship: a practical handbook for patients, written by Max Mano, a renowned Brazilian oncologist specialized in treating breast cancer, provides guidance to patients who are facing...
Navegando Pelo Diagnóstico, Tratamento e Sobrevivência do Câncer de Mama: Um Livro de Bolso Para Pacientes A sobrevivência ao câncer é um campo relativamente novo em oncologia, embora seja cada vez mais importante. Quando se trata de câncer de mama, por se tornar uma condição altamente curável, a sobrevivência é um assunto atual a ser discutido pelos médicos e – por que não? – pelos pacientes e suas famílias. No entanto, muitos livros sobre sobrevivência ao câncer centram-se em questões gerais de saúde e nos efeitos secundários dos tratamentos, deixando de lado o que os pacientes deveriam saber sobre o assunto. Navegando pelo diagnóstico, tratamento e sobrevivência ...
O mundo dos investimentos pode parecer um mistério ou até mesmo algo assustador para quem não sabe como utilizar bem o seu dinheiro. O risco de perder o valor investido é o que mais assombra aqueles que ainda não se aventuraram nessa área. Para muitos médicos, mais ligados às questões técnicas da sua profissão, tudo isso pode parecer distante e fora da sua realidade. Com o livro Bolsa de Valores para Médicos, que chega agora em sua segunda edição, os autores Francinaldo Lobato Gomes e Francisco Vaz Guimarães Filho mostram que os investimentos não precisam ser um bicho-de-sete-cabeças para os profissionais da Saúde. Aplicar o dinheiro em ações, construindo uma carteira ren...
Avant d'entrer dans une nouvelle phase, Brésil(s) republie, dans le numéro zéro, une anthologie d'articles sélectionnés parmi la vaste collection offerte par la revue depuis sa fondation en 1987.
This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students.
Occupational Safety and Hygiene VI collects recent papers of selected authors from 21 countries in the domain of occupational safety and hygiene (OSH). The contributions cover a wide range of topics, including: - Occupational safety - Risk assessment - Safety management - Ergonomics - Management systems - Environmental ergonomics - Physical environment - Construction safety, and - Human factors Occupational Safety and Hygiene VI represents the state-of-the-art on the above mentioned domains, and is based on research carried out at universities and other research institutions. Some contributions focus more on practical case studies developed by OSH practitioners within their own companies. Hence, the book provides practical tools and approaches currently used by OHS practitioners in a global context.