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Leading investigators review the highlights of current fibrosis research and the experimental methodologies used uncover the mechanisms that drive it. In their discussion of research methodologies utilizing cultured cells to model various aspects of the fibrotic response in vitro, the authors describe the isolation, characterization, and propagation of mesenchymal cells, and highlight the similarities and differences between methods that are appropriate for different types of fibroblasts. Approaches for studying collagen gene regulation and TGF-b production are also discussed, along with experimental methodologies utilizing animal models to study the pathogenesis of fibrosis. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Tonino Valerii is one of Italy's best genre film directors. Starting out as Sergio Leone's assistant on For a Few Dollars More (1965), he went on to direct spaghetti westerns that stand out among the most accomplished in their class--Day of Anger (1967), The Price of Power (1969), A Reason to Live, a Reason to Die! (1972) and My Name Is Nobody (1973). He also directed the outstanding giallo My Dear Killer (1972). This book examines Valerii's life and career in depth for the first time, with exclusive interviews with the filmmaker, scriptwriters and actors, and critical analysis of his films.
This book collects the publications of the special Topic Scientific advances in STEM: from Professor to students. The aim is to contribute to the advancement of the Science and Engineering fields and their impact on the industrial sector, which requires a multidisciplinary approach. University generates and transmits knowledge to serve society. Social demands continuously evolve, mainly because of cultural, scientific, and technological development. Researchers must contextualize the subjects they investigate to their application to the local industry and community organizations, frequently using a multidisciplinary point of view, to enhance the progress in a wide variety of fields (aeronaut...
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Author of the influential Relational Aesthetics examines the dynamics of ideology Leading theorist and art curator Nicolas Bourriaud tackles the excluded, the disposable and the nature of waste by looking to the future of art—the exform. He argues that the great theoretical battles to come will be fought in the realms of ideology, psychoanalysis and art. A “realist” theory and practice must begin by uncovering the mechanisms that create the distinctions between the productive and unproductive, product and waste, and the included and excluded. To do this we must go back to the towering theorist of ideology Louis Althusser and examine how ideology conditions political discourse in ways that normalize cultural, racial and economic practices of exclusion.
The first book of its kind, Environmental Electrochemistry considers the role that electrochemical science and engineering can play in environmental remediation, pollution targeting, and pollutant recycling. Electrochemical-based sensors and abatement technologies for the detection, quantification, and treatment of environmental pollutants are described. Each chapter includes an extensive listing of supplemental readings, with illustrations throughout the bookto clarify principles and approaches detailed in the text. Key Features * The first book to review electro- and photoelectrochemical technologies for environmental remediation, pollution sensors and pollutant recycling * Applicable to a broad audience of environmental scientists and practicing electrochemists * Includes both laboratory concepts and practical applications
After the success of The Northern Clemency, shortlisted for the 2008 Man Booker Prize, Philip Hensher brings us another slice of contemporary life, this time the peaceful civility and spiralling paranoia of a small English town.
Seventeen-year-old Miguel Angel spends every minute after school at the Packing Shed, working out with the Alisal Boxing Club. He dreams of becoming a champion so he can get his mother and five siblings out of their cramped one-bedroom apartment in one of Salinas' poorest barrios. But suddenly his life gets more complicated. The city is threatening to take the Packing Shed away from Coach, and without a place to train he won't be able to avoid the gangbangers in his neighborhood. His childhood friend, Beto, has succumbed to the wiles of easy money and expensive cars, and Miguel Angel wonders if he'll be able to resist his friend. Meanwhile, beautiful blonde Britney from Pebble Beach has ente...