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Fuzziness
  • Language: en

Fuzziness

  • Type: Book
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  • Published: 2011-12-14
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  • Publisher: Springer

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Computational Approaches to Protein Dynamics
  • Language: en
  • Pages: 458

Computational Approaches to Protein Dynamics

  • Type: Book
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  • Published: 2014-12-24
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  • Publisher: CRC Press

The Latest Developments on the Role of Dynamics in Protein FunctionsComputational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, an

Fuzziness
  • Language: en
  • Pages: 210

Fuzziness

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Unfolded Proteins
  • Language: en
  • Pages: 330

Unfolded Proteins

The word revolution has a number of definitions (The American Heritage Dictionary, 2006). The one most pertinent to this series and volume is 'a sudden or momentous change in a situation'. Recent years have seen an unprecedented explosion of interest in unfolded proteins in all of their various forms. Coupled with this increase in interest we have seen momentous changes in the way unfolded proteins are viewed. Two particular paradigms have come under close scrutiny: unfolded proteins are disordered random coils devoid of persistent structure, and protein function first requires protein structure. The first of these is currently a hotly debated subject. The second paradigm we can safely claim...

Computational Protein-Protein Interactions
  • Language: en
  • Pages: 346

Computational Protein-Protein Interactions

  • Type: Book
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  • Published: 2009-06-26
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  • Publisher: CRC Press

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current resear

Exploring Medical Biotechnology- in vivo, in vitro, in silico
  • Language: en
  • Pages: 435

Exploring Medical Biotechnology- in vivo, in vitro, in silico

  • Type: Book
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  • Published: 2024-04-25
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  • Publisher: CRC Press

This book on medical biotechnology offers a wide array of topics and cutting-edge research in the field featuring contributions from multiple authors, each specializing in their respective areas, making it highly valuable to science students and enthusiasts. The book provides comprehensive coverage on a diverse range of topics including sequence analysis, network pharmacology, drug discovery, CRISPR-Cas technology, precision medicine, neuroimaging biomarkers, therapeutics for neurodegenerative diseases, molecular pathogenesis of various diseases, plant-derived antioxidants, genetic approaches for disease diagnosis, cancer progression, immunotherapy, cancer biomarker identification, RNA Inter...

What is Expression?
  • Language: en
  • Pages: 303

What is Expression?

  • Type: Book
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  • Published: 2010-02
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  • Publisher: iUniverse

What are the elements of expression? What are the origins, aims, and functions of expression? An adequate theory of expression can help us to address these questions and to recognize the diversity of the many modes of expression (scientific, ethical, aesthetic, religious, and sociocultural). Alex Scott describes the interdependence of the modes of expression, showing that a theory of expression can promote social understanding by illuminating the nature of our interdependence as individuals in society. Expression theory, as described by Scott, is not merely a theory of art. It is a theory of the ethics, aesthetics, psychology, logic, language, and politics of expression. It is a theory that ...

Endocrine FGFs and Klothos
  • Language: en
  • Pages: 250

Endocrine FGFs and Klothos

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

Grey Aliens and the Harvesting of Souls
  • Language: en
  • Pages: 504

Grey Aliens and the Harvesting of Souls

Exposes the agenda behind the bio-robotic grey aliens’ genetic manipulation of certain human races • Reveals the Grey’s nature as sophisticated self-aware machines created by a long vanished extraterrestrial civilization • Explains how their quest to capture human souls appears in the historical record from biblical times • Explains how the phenomenon of racism is a by-product of their genetic tampering In 1997 Nigel Kerner first introduced the notion of aliens known as Greys coming to Earth, explaining that Greys are sophisticated biological robots created by an extraterrestrial civilization they have long since outlived. In this new book Kerner reveals that the Greys are seeking ...

Structural Bioinformatics of Membrane Proteins
  • Language: en
  • Pages: 287

Structural Bioinformatics of Membrane Proteins

This book is the first one specifically dedicated to the structural bioinformatics of membrane proteins. With a focus on membrane proteins from the perspective of bioinformatics, the present work covers a broad spectrum of topics in evolution, structure, function, and bioinformatics of membrane proteins focusing on the most recent experimental results. Leaders in the field who have recently reported breakthrough advances cover algorithms, databases and their applications to the subject. The increasing number of recently solved membrane protein structures makes the expert coverage presented here very timely. Structural bioinformatics of membrane proteins has been an active area of research over the last thee decades and proves to be a growing field of interest.