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Systemic Inflammation in Severe Infectious Diseases
Hospital-acquired infections are common and often result in life-threatening complications, mostly facing critically ill patients in the intensive care unit. Patients with hospital-acquired infections may die from bacteremia/fungal/viral infection or hyperinflammatory complications because of an uncontrolled over-activation of the innate immune system with pathological levels of circulating proinflammatory cytokines, or from multiorgan failure. In addition to eliciting a robust inflammatory response, it paradoxically renders the host in an immunocompromised state at the late stage of the disease progression. Severe infectious diseases, including sepsis and septic shock are among the most common reasons for death in hospitals. Sepsis is an infection-induced syndrome characterized by a generalized inflammatory state and represents a frequent complication in surgical patients and in immunocompromised patients. Sepsis is a common, expensive, and frequently associated with a fatal outcome. Every 3 to 4 seconds somebody dies with sepsis, and it is one of the leading causes of death worldwide.
Optimization of Sustainable Enzymes Production
This book is designed as a reference book and presents a systematic approach to analyze evolutionary and nature-inspired population-based search algorithms. Beginning with an introduction to optimization methods and algorithms and various enzymes, the book then moves on to provide a unified framework of process optimization for enzymes with various algorithms. The book presents current research on various applications of machine learning and discusses optimization techniques to solve real-life problems. The book compiles the different machine learning models for optimization of process parameters for production of industrially important enzymes. The production and optimization of various enz...
Visible Light-Driven Organic Synthesis
Visible Light-Driven Organic Synthesis covers the recent cutting-edge investigations in the field of visible light– driven organic synthesis in a single comprehensive volume. It provides information on rigorously selected reaction schemes and covers new reactions and new methods under visible light photocatalysis. It enlists more than 100 important synthetic strategies/methodologies with particular emphasis on useful reactions for organic synthesis under the mild reaction conditions reported in recent times involving carbon–carbon (C–C) and carbon–heteroatom bond–forming reactions, resulting in a wide spectrum of chemical compounds, providing an outstanding source of information co...
Antiviral and Antimicrobial Smart Coatings
Antiviral and Antimicrobial Smart Coatings: Fundamentals and Applications provides a critical analysis of all types of smart antiviral and antimicrobial coatings currently being researched. The book opens with a discussion of the microbial and viral pathogens, including how to identify them and their interaction with surfaces. The next three sections look at the concept of smart coatings, specifically antibacterial, antifungal, and antiviral smart coatings, types, effects, and applications. The book concludes by discussing the methods and standards for characterization of coatings and then presents several real world case studies. A valuable resource for those working in the smart coatings field. Introduces the concepts of smart coatings and the synthesis, characterization, and classification Provides insights into the pros and cons of established processes and thereby provides guidance on how to select the appropriate techniques for specific applications Discusses the process of applying smart antimicrobial and antiviral coatings on various surfaces Presents the methods for characterization of smart and multifunctional coatings
Targeting PI3K/mTOR signaling in cancer
The phosphatidylinositol 3-kinase (PI3K)/mTOR pathway integrates signals from growth factors with nutrient signals and other conditions and controls multiple cell responses, including proliferation, survival and metabolism. Deregulation of the PI3K pathway has been extensively investigated in connection to cancer. Somatic or inherited mutations frequently occur in tumor suppressor genes (PTEN, TSC1/2, LKB1) and oncogenes (PIK3CA, PIK3R1, AKT) in the PI3K/mTOR pathway. The fact that the PI3K/mTOR pathway is deregulated in a large number of human malignancies, and its importance for different cellular responses, makes it an attractive drug target. Pharmacological PI3K inhibitors have played a ...
Molecular Biotechnology
PART I MOLECULAR BIOLOGY An Introduction to Molecular Biotechnology Genetic Material DNA Replication and Repair Gene Concept Transcription or Gene Expression Translation PART II GENETICS Regulation of Gene Expression Mendel’s Laws Gene Interaction Linkage and Crossing Over Mutations Bacterial Recombination Transposons Chloroplast and Mitochondrial Genome Organization PART III GENETIC ENGINEERING Gene Cloning Enzymes Used in Genetic Engineering Bacterial Vectors Blotting Techniques Generation of Clones DNA Libraries Polymerase Chain Reaction DNA Synthesis by Chemical Method Restriction Fragment Length Polymorphism Gene Transfer Methods Application of Recombinant Technology.
Data Lake Development with Big Data
Explore architectural approaches to building Data Lakes that ingest, index, manage, and analyze massive amounts of data using Big Data technologies About This Book Comprehend the intricacies of architecting a Data Lake and build a data strategy around your current data architecture Efficiently manage vast amounts of data and deliver it to multiple applications and systems with a high degree of performance and scalability Packed with industry best practices and use-case scenarios to get you up-and-running Who This Book Is For This book is for architects and senior managers who are responsible for building a strategy around their current data architecture, helping them identify the need for a ...
Modeling and Simulation of Fluid Flow and Heat Transfer
In the rapidly advancing modern world, scientific and technological understanding and innovation are reaching new heights. Computational fluid dynamics and heat transfer have emerged as powerful tools, playing a pivotal role in the analysis and design of complex engineering problems and processes. With the ability to mathematically model various engineering phenomena, these computational tools offer a deeper understanding of intricate dynamics before the physical prototype is created. Widely employed as simulation tools, computational fluid dynamics and heat transfer codes enable the virtual or digital prototype development of products and devices involving complex transport and multiphasic ...
Nutraceuticals, Glycemic Health and Type 2 Diabetes
Type 2 diabetes is a growing problem for the developed and developing countries and it is a burden on healthcare systems as well as individuals. Nutraceuticals, Glycemic Health and Type 2 Diabetes primarily focuses on the nutraceuticals that assist in preventing and managing prediabetes and type 2 diabetes. The book gives an overview of glycemic health and highlights the use of novel and upcoming nutraceutical ingredients such as bioactive peptides, traditional herbs from China, India and Mexico, resistant starches, cinnamon, chromium and others. After the successful commercial application of bioactive peptides as nutraceutical ingredients in the management of blood pressure, companies are n...
Antimicrobial Peptides and Human Disease
Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.
