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Voltage-Gated Ion Channels as Drug Targets
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
Encyclopedia of Molecular Pharmacology
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
The Hand of Destiny
Rajalakshmi Meenakshisundaram, a traditional, god-fearing wife and mother, has led a sheltered life in India. Her happy world in Chennai is shattered when her only child, Venkat, dies on his birthday, the victim of a terrorist attack in France. She must now travel to Paris with her husband to claim Venkat’s body. Katherine Mary Flannigan, a mother of three, is a loving wife and staunch church goer. The Irish Flannigans have lived in the little town of Blue Hampton, outside London, for generations. Jonas, her eldest son has been missing for a week when she learns that he has blown himself to bits in France, having secretly converted to Islam just a year before. The village is split on accep...
Pollution Prevention through Process Integration
The environmental impact of industrial waste is one of the most serious challenges facing the chemical process industries. From a focus on end-of-pipe treatment in the 1970s, chemical manufacturers have increasinglyimplemented pollution prevention policies in which pollutants are mitigated at the source or separated and recovered and then reused or sold. This book is the first to present systematic techniques for cost-effective pollution prevention, altering what has been an art that depends on experience and subjective opinion into a science rooted in fundamental engineering principles and process integration. Step-by-step procedures are presented that are widely applicable to the chemical,...
Process Integration
With growing global competition, the process industries must spare no effort in insuring continuous process improvement in terms of Increasing profitability; Conservation of resources and Prevention of pollution. The question is how can engineers achieve these goals for a given process with numerous units and streams? Until recently conventional approaches to process design and operation put emphasis only on individual units and parts of the process. A more powerful integrated approach was lacking. The new field of Process Integration looks towards the processing plant as a whole in its attempt to find solutions and improvements. Research over the past two decades has resulted in many techni...
