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Design of Hybrid Molecules for Drug Development
Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheim...
Progress in Botany Vol. 81
With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. The present volume includes reviews on plant physiology, biochemistry, genetics and genomics, forests, and ecosystems.
Language Awareness in Multilingual Classrooms in Europe
Within the scope of today’s globalisation, linguistic diversity is a given fact of the world we live in. In several educational contexts in Europe, language awareness (LA) activities have been introduced with the objective to prepare pupils cognitively, socially and/or critically for life as multilingual, open minded and/or empowered citizens in a diverse world. Despite previous research in various contexts, the concept of LA remains problematic: a generally accepted, evidence-based conceptualisation is missing. This confronts both research and education with a challenge: in order to develop LA activities, implement them successfully in educational contexts and achieve the expected outcome...
The Past in the Present
The Past in the Present deals with the complexities in the operation and management of living heritage sites. It presents a new interpretation of such sites based on the concept of continuity, and its evolution to the present. It is demonstrated that the current theoretical framework and practice of conservation, as best epitomised in a values-based approach and the World Heritage concept, is based on discontinuity created between the monuments (considered to belong to the past) and the people of the present, thus seemingly unable to embrace living heritage sites. From this position, the study suggests an innovative approach that views communities and sites as an inseparable entity: a Living...
Nutritional Bioavailability of Iron
Abstract: Research results concerning aspects of iron (Fe) bioavailability from various foods and interactions of Fe with other nutrients are reported by experts for nutritionists and food and agricultural chemists. Several areas address the determination of available Fe in foods, changes in Fe availability caused by food processing, physiochemical food properties affecting Fe chemstry, and food additives that either enhance or inhibit Fe intake. Therelationship of ascorbic acid in aiding Fe absorption is discussed, as is the inhibitory action of dietary fiber. Twoimportant human nutrition aspects cover Fe availability in human milk, and the differences in Fe utilization between vegetarians and omnivores. When careful choice is made of food combinations, food additives, and proper processing methods, humans can utilize a greater portion of the Fe in low-energy foods. (wz).
Nutrition in Early Life
The publication of the Department of Health White Paper "The Health of the Nation" (1992) and "Our Healthier Nation" (1998) gave emphasis to the importance of nutritional health of the nation at all ages. It is clear that the achievement of specific targets for pregnancy and infancy as set out in the White Paper will involve the training of all health care professionals in nutrition education. This book responds to the challenge and focuses on good nutrition for and during pregnancy, in low birth-weight infants, and during infancy. It has a strong public health emphasis, dealing with health prevention issues for the Nation's younger population. The text is written as a scientific reference book for those seeking to apply science in the support of a successful pregnancy and in the prevention of nutritional problems during foetal and early post-natal life. The importance of optimal nutrition during these periods of life is emphasised by the overwhelming evidence that nutritional problems in early embryonic life may cause congenital malformations and during late foetal life and early post natal life may set the molecular programme for later disease development.
Mathematical Reviews
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Analgesia in Major Abdominal Surgery
This book presents current evidence in an Enhanced Recovery Programme context, and provides a common sense approach to using the array of available analgesia techniques appropriately in major abdominal surgery. Current pain relief options are discussed, many of which have been described only in the last ten years. Topics covered range from the now widespread use of portable ultrasound machines to an appreciation of the value of some older drugs in a new context. Analgesia for Major Abdominal Surgery is aimed at anesthetists, acute pain teams, and acute pain nurses, as well as colorectal, hepatobiliary, urological and gynecological surgeons.
Environment, Power, and Society for the Twenty-First Century
Howard T. Odum possessed one of the most innovative minds of the twentieth century. He pioneered the fields of ecological engineering, ecological economics, and environmental accounting, working throughout his life to better understand the interrelationships of energy, environment, and society and their importance to the well-being of humanity and the planet. This volume is a major modernization of Odum's classic work on the significance of power and its role in society, bringing his approach and insight to a whole new generation of students and scholars. For this edition Odum refines his original theories and introduces two new measures: emergy and transformity. These concepts can be used t...
