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Drug Metabolism
With its roots in the last century and currently exploiting the technology of today, the science of drug metabolism has made significant contributions to our understanding of chemico-biological interactions. This book reviews past successes and failures within the science and attempts to predict new directions. Each of the chapters of this book deals with an aspect of xenobiotic metabolism which has featured prominently in the development of the discipline. The volume is testimony to the breadth and depth of research into xenobiotic metabolism and covers the chemistry and enzymology of xenobiotic metabolism, enzyme modeling and structure activity relationships, pharmacokinetics, the use of r...
Toxicology- From Cells to Man
Renal transport and xenobiotic metabolism play an important role in the detoxication and excretion of potentially toxic xenobiotics. However, recent experimental evidence has demonstrated that renal xenobiotic metabolism and renal transport processes also play an important role in the nephrotoxicity of xenobiotics and xenobiotic metabolites. The high blood flow to the kidney combined with its ability to concentrate solutes may expose the kidney to high concentrations of xenobiotics and xenobiotics metabolites present in the systemic circulation. Recently, it has been demonstrated that xenobiotic metabolites formed in the liver and other organs may be targeted to the kidney by selective trans...
Advances in Nucleic Acid Therapeutics
The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.
Mechanobiology
Until the '90s, research in biomechanics and biorheology mainly focused on tissues and cell priorities, so as to identify the bioclinical problems linked to the rheology properties of cells and tissues or to develop substitutes. Advances in molecular biology and new knowledge in cellular biology over the last ten years have given access to a more physiological approach to the effects of stress on cells and tissues.
Prevention and Health Promotion for the Excluded and the Destitute in Europe
The social inequalities of health have persisted, or even increased, in Europe in the last few years. This text presents the experiences of professionals from various institutional backgrounds in eight European countries, as well as their recommendations to improve the access of excluded people.
Advances in Molecular Toxicology
Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advan...
Environmental Analysis
"Environmental Analysis" covers a compilation of analytical methods for the determination of a wide range of environmental priority pollutants, including amines, polycyclic aromatic hydrocarbons, pesticides, phenols, PCBs, and also including organometallic species, polycyclic aromatic sulphur heterocycles and metabolites of polycyclic aromatic hydrocarbons. For all environmental pollutants, an overview and an assessment of value of a broad range of relevant methods including conventional techniques but also of advanced separation and sample preparation techniques given, with all possible matrices being considered. This book does not only give up-to-date material on sampling and sample pre-tr...
The European Union and Health Services
While most Member States Governments have assumed that they have full responsibility and control over their own health services it is becoming increasingly apparent that the Single European Market is having a substantial impact on health services. Recent rulings by the European Court of Justice (ECJ) have, in particular, established the freedom of citizens to choose health care goods and services across borders. To examine the actual relationship between the SEM and health services, this book: - identifies SEM regulations and directives as well as ECJ decisions which explicitly refer to health services and which therefore have a potential impact on the purchasing, supply and delivery of health services, - evaluates the impact of SEM regulations and ECJ decisions on the purchasing, supply and delivery of health services, - identifies outcomes, including both intended and unintended effects, of the SEM on Member States' health services and - develops future scenarios exploring key issues identified in the earlier analysis and evaluation.
