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The essence of brain function consists in how information is processed, transferred and stored. Current neurophysiological doctrine remains focused within a spike timing paradigm, but this has a limited capacity for advancing the understanding of how the brain works. This book puts forward a new model; the neuroelectrodynamic model (NED), which describes the intrinsic computational processes by the dynamics and interaction of charges. It uses established laws of physics, such as those of classical mechanics, thermodynamics and quantum physics, as the guiding principle to develop a general theoretical construct of the brain s computational model, which incorporates the neurobiology of the cel...
There is no doubt that if the field of exercise physiology is to make further advancements, the various specialized areas must work together in solving the unique and difficult problems of understanding how exercise is initiated, maintained and regulated at many functional levels, and what causes us to quit. Exercise is perhaps the most complex of physiological functions, requiring the coordinated, integrated activation of essentially every cell, tissue and organ in the body. Such activation is known to take place at all levels - from molecular to systemic. Focusing on important issues addressed at cellular and systemic levels, this handbook presents state-of-the-art research in the field of...
The EUROHIS project has focused on the comparability of health surveys and has uncovered some problems that arise when aiming to compare data from different countries. Similar problems of cross-cultural comparability also arise when comparing data from other sources, such as health registers, and are just as complex and difficult to tackle. One of the main advantages of health surveys, however, is the relatively low cost and time involved in adapting them according to the needs of health policy-makers. This work shows that the output from the EUROHIS project provides common instruments for the measurement of eight health indicators. The development of these instruments has required careful consideration of relevant common concepts and how these should be defined and operationalized. The instruments are freely available for use by all countries, with the aim of enhancing national health information systems and facilitating cross-national comparisons of health data.
." . . based on a conference that was held at the National Institutes of Health in December 2005 to promote historical research on biomedical science in the twentieth century"--p. ix.
The purpose of an exercise in differential diagnosis is to establish crosslinks between medical facts stored in different sections of our memory. This book, Differential Diagnosis in Neurology, is the unified perspective of an eminent physician with decades of clinical experience and teaching; one of the most skilled clinical neurologists of modern times and a seasoned researcher who was the primary investigator for many clinical trials, and who published numerous clinical and basic research papers. The “real world” aspects of the book are based on morning reports with neurology residents and students conducted over 40 years. The differential diagnosis generated by subspecialty division ...
This extraordinary book covers the extremely broad subject of electropharmacology-defined here as the application of principles and methods of electrochemistry to biological topics associated with the action of drugs. It focuses on the physical principles of the movement of electrical charges across interfaces in pharmacological phenomena. It also covers drugs and the electrical procedures which modify a natural process having an electrochemical basis or component. This outstanding report studies the pharmacologically important properties and effects by electrochemical methods, the electrochemical alternatives or adjuncts to drug therapy, and the pharmacology involved. Easy to read and understand, this is an ideal reference for all researchers and practitioners of pharmacology and related fields.
Most patients who develop the eating disorders are frightened of gaining weight. The disordered eating can be viewed as a pathological reaction to this fear and a distorted attempt to establish control of body weight. This book focuses on the place of drugs in the treatment of both sets of illnesses. It addresses the science of eating behavior.
Provides insights not only into the work of the National Institutes of Health, but the relationship between institutional and governmental structures and the manner in which they influenced the direction taken by individual scientists. The recollections of the individuals in the intramural program juxtaposed alongside whatever primary sources have survived also provide an equally fascinating contrast. It provides a perspective that can illuminate contemporary policy debates about the nature and direction of biomedical and social science research as well as the relationships between government and science.
This work covers review articles and research articles related to the "Bioactive Drugs in Drug Discovery Design". It covers the synthesis and properties of bioactive molecules and enzymes, the role of membranes in drug activity and formulation.