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Clinical Genetics and Genomics of Aging
The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components ref...
Principles of Genetics and Molecular Epidemiology
This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles. Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice.
Epigenetics in Human Disease
Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, thi...
Biotechnology and Drug Development for Targeting Human Diseases
Biotechnology and Drug Development for Targeting Human Diseases is an insightful compendium on drug development technologies for professionals and students in biotechnology and pharmacology. This book meticulously explores the intersection of biotechnology with drug development, emphasizing its crucial role in creating new therapies for human disease. Central to the book is the innovative use of biotechnology in understanding and treating diseases. It begins with an exploration of multi-omics profiles, shedding light on disease mechanisms and drug development. Subsequent chapters explain in silico methods for drug design, the role of natural products in antimicrobial applications and wound h...
I Didn't Talk
The English-language debut of a master stylist: a compassionate but relentless novel about the long, dark harvest of Brazil’s totalitarian rule A professor prepares to retire—Gustavo is set to move from Sao Paulo to the countryside, but it isn’t the urban violence he’s fleeing: what he fears most is the violence of his memory. But as he sorts out his papers, the ghosts arrive in full force. He was arrested in 1970 with his brother-in-law Armando: both were vicariously tortured. He was eventually released; Armando was killed. No one is certain that he didn’t turn traitor: I didn’t talk, he tells himself, yet guilt is his lifelong harvest. I Didn’t Talk pits everyone against the ...
Home Reading Service
In this poignant novel, a man guilty of a minor offense finds purpose unexpectedly by way of his punishment—reading to others. After an accident—or “the misfortune,” as his cancer-ridden father’s caretaker, Celeste, calls it—Eduardo is sentenced to a year of community service reading to the elderly and disabled. Stripped of his driver’s license and feeling impotent as he nears thirty-five, he leads a dull, lonely life, chatting occasionally with the waitresses of a local restaurant or walking the streets of Cuernavaca. Once a quiet town known for its lush gardens and swimming pools, the “City of Eternal Spring” is now plagued by robberies, kidnappings, and the other myriad ...
Self Portrait in Green
'NDiaye is a hypnotic storyteller with an unflinching understanding of the rock-bottom reality of most people's life.' New York Times ' One of France's most exciting prose stylists.' The Guardian. Obsessed by her encounters with the mysterious green women, and haunted by the Garonne River, a nameless narrator seeks them out in La Roele, Paris, Marseille, and Ouagadougou. Each encounter reveals different aspects of the women; real or imagined, dead or alive, seductive or suicidal, driving the narrator deeper into her obsession, in this unsettling exploration of identity, memory and paranoia. Self Portrait in Green is the multi-prize winning, Marie NDiaye's brilliant subversion of the memoir. Written in diary entries, with lyrical prose and dreamlike imagery, we start with and return to the river, which mirrors the narrative by posing more questions than it answers.
The Mosquito Bite Author
Originally published in 2011, The Mosquito Bite Author is the seventh novel by the acclaimed Turkish author Barış Bıçakçı. It follows the daily life of an aspiring novelist, Cemil, in the months after he submits his manuscript to a publisher in Istanbul. Living in an unremarkable apartment complex in the outskirts of Ankara, Cemil spends his days going on walks, cooking for his wife, repairing leaks in his neighbor’s bathroom, and having elaborate imaginary conversations in his head with his potential editor about the meaning of life and art. Uncertain of whether his manuscript will be accepted, Cemil wavers between thoughtful meditations on the origin of the universe and the trajectory of political literature in Turkey, panic over his own worth as a writer, and incredulity toward the objects that make up his quiet world in the Ankara suburbs.
Proteome Research: Two-Dimensional Gel Electrophoresis and Identification Methods
With the end of the Human Genome Project in sight, the next important step is to determine the function of genes. Proteome Research is an important approach to this study and is the first book to comprehensively cover the application of two-dimensional electrophoresis, the central methodology in proteome research. The state-of-the-art is described in detail and the available detection methods are extensively covered. Sufficient detail is given to allow readers to apply these technologies to their own particular requirements.
Minor Detail
From a young Palestinian writer comes this compelling look at the Israel/Palestine conflict, from both the perspective of an Israeli soldier in 1949 as well as that of a young Palestinian woman.
