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PI3K-mTOR in Cancer and Cancer Therapy
In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority o...
Latecomer State Formation
A major contribution to the field of comparative state formation and the scholarship on long-term political development of Latin America "Ambitious and rich. . . . A sweeping and general theory of state formation and detailed historical reconstruction of essential events in Latin American political development. It combines structural elements with a novel emphasis on the political incentives and bargaining that shaped the map we have today."--Hillel David Soifer, Governance Latin American governments systematically fail to provide the key public goods for their societies to prosper. Sebastián Mazzuca argues that the secret of Latin America's failure is that its states were "born weak," in c...
Cytokines and the CNS
Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelera
Predictive Biomarkers in Oncology
“Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledg...
Madness in the Family
Madness in the Family traces the history of how family became crucial in the care of those considered mad, as well as in creating gendered explanations of madness, in turn-of-the-twentieth-century Japan. As women and families navigated a shifting therapeutic landscape of madness, they produced their own understandings and approaches to madness that, like elsewhere in the world, would take precedence over the claims of psychiatry, the law, and the state in everyday life.
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
AACR 2019 Proceedings: Abstracts 2749-5314
American Association for Cancer Research 2019 Proceedings: Abstracts 2749-5314 - Part B
Immigrant Incorporation in East Asian Democracies
Comparing three Northeast Asian countries, this book examines how past struggles for democracy shape current movements for immigrant rights.
AACR 2017 Proceedings: Abstracts 1-3062
The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside their own areas of expertise, and learn how to apply exciting new concepts, tools, and techniques to their own research. Part A contains abstracts 1-3062 accepted for the 2017 meeting.
