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The Carbonic Anhydrases
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
Schaum's Outline of Computer Architecture
A problem/solution manual, integrating general principles and laboratory exercises, that provides students with the hands-on experience needed to master the basics of modern computer system design Features more than 200 detailed problems, with step-by-step solutions; many detailed graphics and charts; chapter summaries with additional "rapid-review" questions; and expert sidebar tips Describes analytical methods for quantifying real-world design choices regarding instruction sets, pipelining, cache, memory, I/O, and other critical hardware and software elements involved in building computers An ideal educational resource for the more than 70,000 undergraduate and graduate students who, each year, enroll in computer architecture and related courses
Dropping the Torch
Dropping the Torch: Jimmy Carter, the Olympic Boycott, and the Cold War offers a diplomatic history of the 1980 Olympic boycott. Broad in its focus, it looks at events in Washington, D.C., as well as the opposition to the boycott and how this attempted embargo affected the athletic contests in Moscow. Jimmy Carter based his foreign policy on assumptions that had fundamental flaws and reflected a superficial familiarity with the Olympic movement. These basic mistakes led to a campaign that failed to meet its basic mission objectives but did manage to insult the Soviets just enough to destroy détente and restart the Cold War. The book also includes a military history of the Soviet invasion of Afghanistan, which provoked the boycott, and an examination of the boycott's impact four years later at the Los Angeles Olympics, where the Soviet Union retaliated with its own boycott.
The Carbonic Anhydrases: Current and Emerging Therapeutic Targets
This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
Re-Coil
The Expanse meets Altered Carbon in this breakneck science fiction thriller where immortality is theoretically achievable, yet identity, gender and selfhood are very much in jeopardy... Carter Langston is murdered whilst salvaging a derelict vessel - a major inconvenience as he's downloaded into a brand-new body on the space station where he backed up, several weeks' journey away. But events quickly slip out of control when an assassin breaks into the medbay and tries to finish the job. Death no longer holds sway over a humanity that has spread across the solar system: consciousness can be placed in a new body, or coil, straight after death, giving people the potential for immortality. Yet Carter's backups - supposedly secure - have been damaged, his crew are missing, and everything points back to the derelict that should have been a simple salvage mission. With enemies in hot pursuit, Carter tracks down his last crewmate - re-coiled after death into a body she cannot stand - to delve deeper into a mystery that threatens humanity and identity as they have come to know it
Advances in Human Genetics
1 Vitamin-Responsive Inherited Metabolic Disorders.- Vitamin Deficiency: Historical Perspective.- Vitamin Responsiveness or Dependency.- Genetic Control of Vitamin Metabolism.- Biochemical Role of Vitamins.- Effect of Mutation on Vitamin Function: Theoretical Possibilities.- Defects of Vitamin Transport and Coenzyme Synthesis.- Cobalamin (Vitamin B12).- Folic Acid.- Calciferol (Vitamin D).- Defects of Coenzyme-Dependent Apoenzymes.- Pyridoxine (Vitamin B6).- Biotin.- Thiamine (Vitamin B1).- Genetic Heterogeneity.- Clinical Panorama.- Mendelian Inheritance.- Prenatal Detection and Treatment.- P.
The Carbonic Anhydrases
As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant decrease in a 3 hydroxyl ion. Globally, the functions of the carbonic anhydrases in photosynthesis in rain forests and in the algae and plankton that cover our oceans indicate that they are also of utmost import...
Survey of Food and Nutrition Research in the United States
A Compilation or Research Pertaining to Foods and Nutrition in Academic, Gevernmental and Industrial Laboratories.
