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This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
To comprehend the world around us, we first have to decipher how our brains work. This book outlines a new approach to knowledge and comprehension based on the elucidation of several basic neuronal mechanisms. It explores the crucial fact that unconscious processes and conscious experiences form a continuum and, importantly, introduces the concept of metarepresentations. This fundamental notion captures the essence of being human, namely, what separates us from our evolutionary predecessors. Important examples of metarepresentations are language, mathematics, technology and the arts. The interdisciplinary, integrative approach of this book demonstrates how different disciplines and notions which appear disconnected are actually closely related. Furthermore, this approach elucidates how we think about topics such as mathematics, physics, painting, music and philosophy. Most significantly, it helps us understand the origin of our thoughts, feelings and actions, bringing deep insight and fulfilment or, more precisely, eudemonia.
Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspect...
Looking to gain a better understanding of the difference between dementia and Alzheimer’s disease? Look no further than this informative and practical guide. With a focus on helping readers maintain their well-being and happiness, this book offers clear explanations of the symptoms associated with both conditions, including common signs like losing items such as keys or glasses, forgetting a friend’s name, or struggling to find the right word. As the symptoms of dementia and Alzheimer’s disease progress, they can significantly interfere with daily life. However, this book provides practical advice that can help individuals and their loved ones navigate these challenges and maintain their quality of life for as long as possible. Whether you are looking to learn more about these conditions for personal or professional reasons, this book is an excellent resource for anyone seeking a deeper understanding of this important topic.
Cell Biology and Biotechnology: Novel Approaches to Increased Cellular Productivity contains the proceedings of the symposium by the same name held in Cambridge, Massachusetts, January 30 - February 2, 1992. State-of-the-art research is presented on: the IGF-1 Receptor and Gene Expression During the Cell Cycle; Attachment Control of Fibroplast Proliferation; Cell Biology and Serum-Free Mouse Embryo Cells; Immunoglobulin Production Stimulating Factors; Erythropoietin Control of Programmed Death in Erythroid Progenitors; Prohormone Processing Enzymes and Protein Production; Control of Translation Initiation by Phosphorylation; Protein Retention in the Endoplasmic Reticulum Mediated by GPR78; Molecular Approaches Towards Manipulating the Expression of the Glucose Related Proteins in Mammalian Cells; Protein Folding in the Endoplasmic Reticulum; Sorting of Membrane Proteins in the Endocytic and Exocytic Pathways; CIS-Acting Elements Which Regulate Immunoglobulin Gene Transcription.
Small GTPases play a key role in many aspects of contemporary cell biology: control of cell growth and differentiation; regulation of cell adhesion and cell movement; the organization of the actin cytoskeleton; and the regulation of intracellular vesicular transport.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.
This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.