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Musicophilia
With an introduction by neuroscientist Daniel Glaser. With his trademark compassion and erudition, Dr Oliver Sacks examines the power of music through the individual experiences of patients, musicians, and everyday people. Among them: a surgeon who is struck by lightning and suddenly becomes obsessed with Chopin; people with ‘amusia’, to whom a symphony sounds like the clattering of poets and pans; and a man whose memory spans only seven seconds – for everything but music. Dr Sacks describes how music can animate people with Parkinson’s disease who cannot otherwise move, give words to stroke patients who cannot otherwise speak, and calm and organize people who are deeply disoriented by Alzheimer’s or schizophrenia. Musicophilia alters our conception of who we are and how we function, and shows us an essential part of what it is to be human.
Vítória Espiritual
Vitória Espiritual: O Poder Transformador de Dizer "Eu me Rendo!" Vitória Espiritual é um livro atemporal e essencial. Quase seis décadas após sua primeira publicação, esta obra continua a influenciar gerações com sua profunda sabedoria espiritual e a mensagem central de completa rendição ao senhorio de Cristo. O teólogo e missionário Eli Stanley Jones argumenta que a chave para alcançar vitória, alegria, paz e propósito na vida está na rendição total a Deus, mantendo esse compromisso ao longo de toda a jornada. O autor destaca que a rendição da vontade é o primeiro passo crucial para a vitória, quando reconhecemos nossa dependência de Deus. A rendição do coração ...
Musicofilia
Un giorno, a New York, Oliver Sacks partecipa all’incontro organizzato da un batterista con una trentina di persone affette dalla sindrome di Tourette: tutti appaiono in preda a tic contagiosi, che si propagano «come onde». Poi il batterista inizia a suonare – e come per incanto il gruppo lo segue con i tamburi, fondendosi in una perfetta sincronia ritmica. Questo stupefacente esempio è solo una particolare variante del prodigio di «neurogamia» che si verifica ogniqualvolta il nostro sistema nervoso ‘si sposa’ a quello di chi ci sta accanto attraverso il medium della musica. Presentando questo e molti altri casi con la consueta capacità di immedesimazione, in Musicofilia Sacks ...
Signal Processing and Machine Learning for Biomedical Big Data
Within the healthcare domain, big data is defined as any ``high volume, high diversity biological, clinical, environmental, and lifestyle information collected from single individuals to large cohorts, in relation to their health and wellness status, at one or several time points.'' Such data is crucial because within it lies vast amounts of invaluable information that could potentially change a patient's life, opening doors to alternate therapies, drugs, and diagnostic tools. Signal Processing and Machine Learning for Biomedical Big Data thus discusses modalities; the numerous ways in which this data is captured via sensors; and various sample rates and dimensionalities. Capturing, analyzin...
St. Nicholas
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Recent Advances in the 3D Physiological Human
Research into the 3D Physiological Human is a very active field focusing on the creation of patient-specific computer models for personalised healthcare. Reporting on how these models can simulate and provide a better understanding of human physiology and pathology, this book also looks at how the evolution and the improvement of technological devices such as scanners, medical instruments, and computer power have helped in our understanding of the human body and its functionalities. The book contains contributions from leading researchers from a variety of disciplines (including computer graphics, biomechanics, knowledge representation, human-machine interfaces etc) associated with medical imaging, simulation, computer-assisted surgery and 3D semantics. Divided into three parts: anatomical and physiological modelling, physically-based simulation, and medical analysis and knowledge management, this book provides a clear picture of the most recent advances in this increasingly important area.
Aerogels Handbook
Aerogels are the lightest solids known. Up to 1000 times lighter than glass and with a density as low as only four times that of air, they show very high thermal, electrical and acoustic insulation values and hold many entries in Guinness World Records. Originally based on silica, R&D efforts have extended this class of materials to non-silicate inorganic oxides, natural and synthetic organic polymers, carbon, metal and ceramic materials, etc. Composite systems involving polymer-crosslinked aerogels and interpenetrating hybrid networks have been developed and exhibit remarkable mechanical strength and flexibility. Even more exotic aerogels based on clays, chalcogenides, phosphides, quantum d...
The Unshakable Kingdom and the Unchanging Person
Jesus swept onto the scene declaring that the Kingdom of God had arrived! He proclaimed that we would experience life at its fullest only when we organize our lives around the Kingdom. E. Stanley Jones suggests that life in any other way is a muddled, maddening, and impossible way to live. Throughout the centuries we have lost the Kingdom as a clearly defined and workable system for order and influence in our daily lives. We have reduced the Kingdom by putting it into narrower molds, a refuge now, a present security, a future hope, anything but the Kingdom as Jesus preached it - God's total answer to man's total need now." Dr. Jones shows us how to claim our spiritual heritage and the abundant life promised us by embracing the Kingdom and Person of Jesus. He suggests how our experience with God and His Kingdom should be taught and shared in the life of the individual, in the life of the church and in the nations of the world.
Research Grants
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Cytotoxic Payloads for Antibody–Drug Conjugates
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (Kadcyla™), brentuximab vedotin (Adcetris™), inotuzumab ozogamicin (Besponsa™), gemtuzumab ozogamicin (Mylotarg™) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages in...
