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Cardiovascular Applications of Stem Cells
The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies,...
Cardiovascular Mechanobiology, 2nd edition
Biomechanical forces play a major role in organ development, shape and function. When exceeding the physiological range, however, they may become detrimental for organ structure and function. This is probably best exemplified by the cardiovascular system, with both the heart and blood vessels being continuously exposed to the biomechanical forces exerted by the flow of blood. In the heart, it is the build-up of pressure inside the ventricles that allows the ejection of blood into the pulmonary and systemic circulation. The luminal diameter of the small arteries in both parts of the circulation determines the resistance to flow. Hence it also determines the level of blood pressure in both the...
Recent Advances in iPSC-Derived Cell Types
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells.Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to mod...
Measuring the Burden of Disease and Returns to Education in Rural West Africa
The success of health economics and its guidance for health policy heavily rests on the availability of reliable empirical evidence on the demographic, economic, and epidemiological environment, on behavioral relationships, and on the impact of policy interventions. For Sub-Saharan Africa, especially the epidemiological situation is unclear, since comprehensive systems of mortality and health statistics are often absent.The economic analysis of health naturally places a special focus on the interrelation between health and economic well-being: the overall disease burden decreases when a country grows richer, and the share of communicable diseases decreases in the process of economic developm...
Handbook of Pediatric Neuro-Ophthalmology
Based on Dr. Wright’s classic major reference, Handbook of Pediatric Neuroophthalmology outlines the latest findings in diagnosing children's eye diseases and their treatment options. Distilling the essentials of ocular manifestations of pediatric neuroophthalmologic disorders and diseases into a portable, complete and authoritative pocket reference, this handbook offers a complete picture of how to best treat pediatric patients. Specifically, the introductory chapters on the specifics of pediatric ophthalmology (embryology, post-natal development and the pediatric exam) will help newcomers to pediatric practice fully grasp the subtle differences in pediatric care. The chapters are written by leading experts in the field and are presented in a user-friendly format, relying on heavily illustrated in color plates, clinically helpful tables, charts, and decision-making guidelines. This approach will enable the practitioner (whether specialist or generalist) to make the most accurate diagnosis and choose the most effective treatment option.
New Economy
For many observers the beginning of a dynamic economic and stock market upswing in the U.S. in the mid 1990s marked the start of a new era, the times of the new economy. This phenomenon has been under intense discussion ever since - both in the political arena as well as among scientists. Thereby the somewhat glamorous term new economy reflects the conviction held by its proponents that the use of new technologies will lead to a never ending acceleration of technological progress and economic welfare.The origins of this development date back a long time: More than 30 years ago, the starting point was the basic innovation "digitilization"". Production as well as application of information and...
The Physics of Cancer
An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.
Climatic Variability in Sixteenth-Century Europe and Its Social Dimension
A multidecadal cooling is known to have occurred in Europe in the final decades of the sixteenth-century. It is still open to debate as to what might have caused the underlying shifts in atmospheric circulation and how these changes affected societies. This book is the fruit of interdisciplinary cooperation among 37 scientists including climatologists, hydrologists, glaciologists, dendroclimatologists, and economic and cultural historians. The known documentary climatic evidence from six European countries is compared to results of tree-ring studies. Seasonal temperature and precipitation are estimated from this data and monthly mean surface pressure patterns in the European area are reconstructed for outstanding anomalies. Results are compared to fluctuations of Alpine glaciers and to changes in the frequency of severe floods and coastal storms. Moreover, the impact of climate change on grain prices and wine production is assessed. Finally, it is convincingly argued that witches at that time were burnt as scapegoats for climatic change.
