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Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis of CAP including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered.
Handbook of Biologically Active Peptides
Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides pres...
Perspectives on Lung Endothelial Barrier Function
Covers endothelial biology from the fundamentals of structure and lung fluid balance physiology to descriptions of the molecular mechanisms involved in the development of lung failure. This illustrated text provides the knowledge of endothelial function, vascular integrity, pulmonary function, and pathophysiology in respiratory failure.
NLR-protein functions in immunity
The Nod-like receptor (NLR) family of proteins are evolutionary conserved molecules that in plants and mammals have been implicated in innate immune sensing of microbes and infection-associated physiological changes, contributing to immune protection of the challenged host organism through the instruction of inflammatory responses, antimicrobial defense and adaptive immunity. Recent data however suggests that the biological roles of NLR go beyond the function of classical pattern recognition molecules (PRM) as they have been implicated in essential cellular processes including autophagy, apoptosis, modification of signal transduction and gene transcription as well as reproductive biology. In...
Differential Diagnosis of Cardiopulmonary Disease
This clinical handbook is designed to aid with the fast and accurate diagnosis of cardiopulmonary disease. Chapters are structured to support the clinical decision-making process and cover key points such as differential diagnosis, typical and atypical presentation, co-morbidities, and critical steps that should not be missed. The text also outlines time-dependent interventions, overall principles of treatment, and disease course. Abundant images and links to external audio and video resources reinforce understanding. Although the chapters are organized to provide ready access to essential information, the scope of the book is comprehensive and addresses topics including acute coronary syndrome, heart failure, pulmonary embolism, primary and secondary lung diseases, and relevant upper gastrointestinal and neuromuscular diseases. Both adult and pediatric considerations are presented. The book is intended for diagnosticians in emergency medicine, critical care, inte rnal medicine, primary care, and related fields. Medical students, residents, and other medical professionals will appreciate the concise and clear approach.
Calmodulin Antagonists and Cellular Physiology
Calmodulin Antagonists and Cellular Physiology focuses on the biochemistry of calmodulin antagonists as regulators of cellular physiology. Emphasis is placed on the use of calmodulin antagonists as an indicator of calmodulin function. The mechanism of action of calmodulin antagonists and their interactions with calmodulin are explored. This book is comprised of 33 chapters and begins with an introduction to the biochemical aspects of calmodulin as well as its distribution and functions, followed by a discussion on how calmodulin antagonists and other agents modulate Ca2+-dependent regulatory systems. The next section is devoted to the mechanism of action of calmodulin antagonists and includes chapters that examine the interaction of various drugs with calmodulin and the structure-activity relationships of calmodulin antagonists. The effects of calmodulin antagonists on cell proliferation and growth are then discussed. The remaining chapters deal with the role of calmodulin antagonists in cell function and the contractile process, along with their effect on protein kinase C. This monograph will be a useful resource for biochemists as well as students and researchers in biochemistry.
Future Research Questions for Improving COPD Diagnosis and Care
Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases that is associated with significant morbidity and mortality worldwide. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Genetic predisposition also plays a major role, which besides toxic exposure type and duration, can determine different disease phenotypes. Patients with COPD often experience troublesome respiratory symptoms, frequent chest infections, and most importantly, are at risk of serious complications such as lung cancer and cardiorespiratory failure. Despite this, there is currently no cure for COPD, but available treatment options (pharmacological, non-pharmacological, and interventional) can help slow disease progression and improve symptoms and quality of life.
Human Airway Inflammation
Rubor (redness), tumor (swelling), calor (heat), and dolor (pain) are the classical signs of inflammation. These features are obvious in the skin, where injury or disease causes flare, wheal, and painful burning sensations. Vasodi- tation underlies the flare and heat, plasma exudation the swelling, and acti- tion of sensory nerves relays pain. In chronic conditions, skin biopsies show inflammatory cell infiltrate. Inflammation is not unique to the skin and contr- utes to disease and repair processes in other organ systems in the body. From the viewpoint of this volume, lung inflammation is now recognized as central to the pathophysiology of a number of severe respiratory conditions, the two ...
Update on the Immune Mechanisms Against Respiratory Pathogens
Respiratory infections are leading causes of mortality and morbidity, with Tuberculosis and lower respiratory tract infections (LRTI) culminating in almost 5 million deaths per year. Respiratory tract infections pose a continuous threat to humans due to their easy dissemination via aerial transmission. Children under the age of five living in developing countries are the most susceptible hosts to a plethora of bacteria and viruses including Mycobacterium tuberculosis, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Klebsiella pneumoniae, Bordetella pertussis, Pseudomonas aeruginosa, Mycoplasma pneumoniae, Influenza virus, Respiratory syncytial virus and metapneumovir...
