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Evolution by Gene Duplication
It is said that "necessity is the mother of invention". To be sure, wheels and pulleys were invented out of necessity by the tenacious minds of upright citi zens. Looking at the history of mankind, however, one has to add that "Ieisure is the mother of cultural improvement". Man's creative genius flourished only when his mind, freed from the worry of daily toils, was permitted to entertain apparently useless thoughts. In the same manner, one might say with regard to evolution that "natural selection mere(y tnodifted, while redundanry created". Natural selection has been extremely effective in policing alleHe mutations which arise in already existing gene loci. Because of natural selection, o...
Neuromuscular Disorders of Infancy, Childhood, and Adolescence
Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science, diagnosis and treatment of neuromuscular disorders in childhood is a timely and needed resource for all clinicians and researchers studying neuromuscular disorders, especially in childhood. The Second Edition is completely revised to remain current with advances in the field and to insure this remains the standard reference for clinical neurologists and clinical research neurologists. The Second Edition retains comprehensive coverage while shortening the total chapter count to be an even more manageable and effective reference. - Carefully revised new edition of the classic reference on neuromuscular disorders in infancy, childhood and adolescence. - Definitive coverage of the basic science of neuromuscular disease and the latest diagnosis and treatment best practices. - Includes coverage of clinical phenomenology, electrophysiology, histopathology, molecular genetics and protein chemistry
Gene's Genes
Advance praise for Gene's Genes "A real page turner. Mystery intertwined with science. Ping and Gretch will win your heart." -Bob Goldberg, Professor of Molecular, Cellular, and Developmental Biology, UCLA, Member US National Academy of Sciences "Murder, mystery, and medicine combine into a real thriller. But plenty of humor, much of it on the black side. I carried it around on my Palm Pilot just to get it read in between my busy medical rounds." -Mark van Wormer, MD, RVT, RDCS, ABAAM Gene Anderson, a renowned geneticist, is hard on the trail of three possible Nobel Prize-winning genes that he believes will transform the world. But his pursuit is derailed when he is accused of committing a s...
The Gene
** NEW YORK TIMES NUMBER ONE BESTSELLER ** The Gene is the story of one of the most powerful and dangerous ideas in our history from the author of The Emperor of All Maladies. The story begins in an Augustinian abbey in 1856, and takes the reader from Darwin’s groundbreaking theory of evolution, to the horrors of Nazi eugenics, to present day and beyond - as we learn to “read” and “write” the human genome that unleashes the potential to change the fates and identities of our children. Majestic in its scope and ambition, The Gene provides us with a definitive account of the epic history of the quest to decipher the master-code that makes and defines humans – and paints a fascinati...
The Reoviridae
It is now just 20 years since Gomatos and his co-workers at the Rocke feller University showed that the nucleic acid in reovirus particles is double-stranded RNA (dsRNA). This discovery created great excitement, for dsRNA was at that time under intense investigation as the replicative form of viral genomes consisting of single-stranded RNA. An equally interesting and important finding followed soon after: it was found that the reovirus genome consists, not of a single nucleic acid molecule, but of 10 discrete "segments," each with its specific sequence content and each transcribed into its own messenger RNA. It is clear now that these segments are genes. Not surprisingly, the availability of...
Recoding: Expansion of Decoding Rules Enriches Gene Expression
The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solv...
If I Had Cleared the Cesspool
It seems like one's childhood memories should be about something a little more pleasant than taking a dip in a cesspool, but that crazy incident remains vivid even today. It did not seem like all that big of a deal at the time, in fact it was funny, once the cleanup was over . Author Richard Scott was five and half years old that day in 1943 when his brother dared him to jump over the cesspool. His little friend Shirley successfully completed the leap, but Scott wasn't as fortunate as he plunged into a stinky mess. To this very day, he attributes some of his amusing life blunders to that failed jump. From early childhood to his retirement years, If I Had Cleared the Cesspool tells the humorous stories in the life of an ordinary man with an unordinary sense of humor. From an encounter with a rattlesnake to learning to drive the Model A and becoming the baseball team's catcher, Scott narrates a delightful chronology of his life. You'll smile, chuckle, and easily relate to Scott's stories about being a fallible, funny, and regular guy.
Pathogenicity Islands and the Evolution of Pathogenic Microbes
It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.
