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Metabolism of Drugs and Other Xenobiotics
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Infectious Complications in Biologic and Targeted Therapies
This book aims to approach the epidemiology, diagnosis and management of infectious complications related to the use of biologic and targeted therapies. The first part is a general overview on the epidemiology and prevention of infections with the use of these agents. Timelines, pre-treatment evaluation, use of vaccines and travel counseling. In the second part, we will analyze the specific risk of infections associated with the use of the most important agents. The third part approach the problem on a syndromic point of view. For example, how to evaluate pulmonary infiltrates in a patient receiving biologic agents. This part III includes the most difficult and conflicting syndromes that clinicians may face when evaluating these patients. This book is intended not only for infectious diseases specialists, but also for different medical specialties prescribing biologic and targeted therapies.
Handbook of Requirements and Business Analysis
Meyer’s Handbook of Requirements and Business Analysis is a comprehensive treatise providing the reader with all the principles and techniques necessary to produce effective requirements. Even the best design, implementation and verification are worthless if they are the solution to the wrong problem. Defining the problem properly is the task of requirements, also known as business analysis. To be successful, a project must apply to requirements the same engineering standards as to other parts of system construction. The Handbook presents a holistic view of requirements including four elements or PEGS: Project, Environment, Goals and System. One of its principal contributions is the defini...
Tests and Proofs
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Coordination Models and Languages
This book constitutes the refereed proceedings of the 7th International Conference on Coordination Models and Languages, COORDINATION 2005, held in Namur, Belgium in April 2005. The 19 revised full papers presented were carefully reviewed and selected from 88 submissions. Among the topics addressed are Web services, safe ambients, process calculus, abstract verification, role-based software, delegation modeling, distributed information flow, adaptive Web content provision, global computing, mobile agents, mobile computing, multithreaded code generation, shared data space coordination languages, automata specifications, time aware coordination, and service discovery.
Object-Oriented Technology. ECOOP 2007 Workshop Reader
This book contains the final reports of 19 workshops held during the 21st European Conference on Object-Oriented Programming, ECOOP 2007, in Berlin, Germany, in July 2007. The 19 collected reports from high-quality workshops - provided by the respective organizers - all are related to selected aspects in the field of object-oriented programming and technology. The reports are ordered in thematic groups on programming languages, aspects, formal techniques, roles, components, software engineering, and applications.
Testing Software and Systems
This book constitutes the refereed proceedings of the 35th IFIP WG 6.1 International Conference on Testing Software and Systems, ICTSS 2023, held in Bergamo, Italy, during September 18-20, 2023. The 13 full papers presented together with 6 short papers and one journal paper were carefully reviewed and selected from 56 submissions. The conference focuses on Test Case Generation; Test Automation and Design; Model Based Testing; and AI and Smart Contracts Testing.
The AST Handbook of Transplant Infections
Whether you need to manage a post-transplant infection or reduce the possibility of infection, you will find effective guidance in this handbook. The work of the American Society of Transplantation Infectious Diseases Community of Practice, this reference exclusively uses tables and flowcharts to speed up decision making. This distinguished group of investigators and teachers provide point of care information on optimum management of infection in adult and pediatric organ and stem cell transplant patients. The unique tables and flowcharts are devised by the authors, backed up with extensive references, making the book a fully researched yet easy to use guide. The fast growing specialty of transplantation will be well served by this book as increasing numbers of successful procedures mean transplant teams have to be ever more alert to the possibility of and need for action in the event of ensuing infection.
Object-Oriented Technology. ECOOP 2008 Workshop Reader
This book contains the final reports of the workshops held during the 22nd European Conference on Object-Oriented Programming, ECOOP 2008, in Paphos, Cyprus, in July 2008. The 11 collected reports from high-quality workshops - provided by the respective organizers - all are related to selected aspects in the field of object-oriented programming and technology. The topics covered span areas related to object-oriented programming and technology, such as programming languages, aspects, parallel computing, formal techniques, software engineering, tools, and applications.
Frontiers in Software Engineering Education
This book constitutes invited papers from the Second International Workshop on Frontiers in Software Engineering Education, FISEE 2023, which took place at the Château de Villebrumier, France, during January 23-25, 2023. The Editorial and the 8 papers included in this volume were considerably enhanced after the conference and during two different peer-review phases. The contributions cover the main topics of the workshop: education in technology and technology for education; new (and fearless) ideas on education; adjustments in teaching during pandemic: experience reports; models for class development; how to design learning objectives and outcomes; labs and practical sessions: how to conduct them; curriculum development; course design; quality course assessment; long-life studies in education; empirical research in SE education; experiences in starting-up new educational systems; blended education. FISEE 2023 is part of a series of scientific events held at the new LASER center in Villebrumier near Montauban and Toulouse, France.
