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This book is the bible of bioluminescence and a must-read not only for the students but for those who work in various fields relating to bioluminescence. It summarizes current structural information on all known bioluminescent systems in nature, from well-studied ones to those that have been seldom investigated.This book remains an important source of chemical knowledge on bioluminescence and, since the second edition's publication in 2012, has been revised to include major developments in two systems: earthworm Fridericia and higher fungi whose luciferins have been elucidated and synthesized. These two new luciferins represent an essential addition to seven previously known, with fully rewritten sections covering this new subject matter.
This book elucidates the economic conditions and policies during the post War Japanese economy from the view point of an influential policy maker. Dr. Osamu Shimomura is one of the most eminent economists in Japan. He entered the Ministry of Finance and played a crucial role in actualizing the High-Growth era from the late 1950s to the early 70s. "The Doubling Income Plan", which is issued by the Ikeda cabinet, originates from him. It should be noted that while most economists held pessimistic view on the future, Shimomura is brave and foresighted. Shimomura’s theory is not merely one of the pioneer works in macroeconomics, but also suits the economic conditions of Japan. Shimomura extends...
This book, written by a distinguished scientist in the field, provides a comprehensive overview of the biochemical aspects of all luminous organisms currently known. It is the first and only book that provides chemical information on all known bioluminescence systems, in a single volume. Some 35 different types of bioluminescence organisms are discussed in 10 chapters. The descriptions include: a history of the discovery of luminescence substances such as luciferins, luciferases and photoproteins; the process of research, explaining how luminescent substances have been isolated and purified; the properties of luminescent substances; and the reaction modes and mechanisms involved, as interpreted currently. Important experimental data and graphs are included in the book, making time-consuming reference searches almost unnecessary. Helpful advice for experimentalists is given in an appendix.
This book narrates the uniquely intertwined life and scientific career of Nobel laureate Osamu Shimomura, with particular attention to his discovery of aequorin and Green Fluorescent Protein (GFP). It includes his early memories of Manchuria and wartime Japan featuring an eyewitness account of the atomic bombing of Nagasaki, his postwar studies and his travels to collect and research more than fifteen bioluminescent species, in locations ranging from Japan to San Juan Island, Bermuda, New Zealand and Norway. Dr Shimomura describes the unique combination of serendipity and perseverance that led ultimately to his 2008 Nobel Prize in chemistry. The book provides an engaging account of the life of a dedicated scientist, emphasizing the value of determination in the pursuit of pure scientific knowledge, and showing how a general understanding of science helped him open up new areas of research that have led to unforeseen applications in cell biology and medicine.
This third Volume of our unique Nobel Collection brings you new, fascinating articles by Nobel Prize winners (called Laureates), written specifically for young minds. These amazing scientists explain their ground-breaking discoveries and how they achieved them, and also share their insights on how to make your own path in a science career in a way that leads to a happy future. Like everything Frontiers for Young Minds publishes, these articles have been reviewed and approved by young students like you! What are the Nobel Prizes? All researchers are working worldwide to add to the sum of human knowledge. Occasionally, brilliant new discoveries can totally transform the way we understand and i...
The discovery of green fluorescent protein revolutionized molecular biology, transforming our study of everything from the AIDS virus to the workings of the brain.
Chemical and Biological Generation of Excited States discusses major aspects of chemical and biological generation of electronic excitation. This book is organized into 11 chapters that focus on both chemi- and bioenergized processes. This book first discusses some of the fundamental aspects of the description of excited state behavior in condensed media. It then examines the field of gas-phase dioxetane chemiluminescence both by itself and in relation to solution-phase studies. The presented analysis is based on statistical mechanics and supported by a very simple limiting case calculation. Chapter 4 describes the state-of-the-art of how excitation yields are determined experimentally in ch...
The Japanese acknowledge that Dr Osamu Shimomura is their most influential post-war economist but his works and his "economic model of Japan" with its key modification of the Keynesian investment-saving equilibrium condition to create an exploding economy, seems to be virtually unknown in the economics departments of Western universities. This book traces the timeline of the development of Investment Credit Creation economics - the economics understanding which has produced explosive economic growth - from its apparent beginning in FDR's USA during 1938-44 through the adoption of almost identical measures in post war Japan, with the active involvement of Dr Osamu Shimomura, and then the transfer of that new system to post-rapprochement China after 1972. In the view of the author, the Tokyo Consensus nations - China, Japan, South Korea and Taiwan - are using and continue to use the mindset of Shimomuran Economics to achieve great economic advantages and the West now needs to learn what part of Asia knows.
Since the discovery of the gene for green fluorescent protein (GFP), derived from jellyfish, this protein that emits a green glow has initiated a revolution in molecular biosciences. With this tool, it is now possible to visualize nearly any protein of interest in any cell or tissue of any species. Since the publication of the first edition, there have been tremendously significant technological advances, including development of new mutant variants. Proteins are now available in yellow and blue, and Novel Fluorescent Proteins (NFPs) have expanded their utility in developing biosensors, biological markers, and other biological applications. This updated, expanded new edition places emphasis on the rise of NFPs, including new chapters on NFP properties with detailed protocols, applications of GFPs and NFPs in industry research, and biosensors. This book provides a solid theoretical framework, along with detailed, practical guidance on use of GFPs and NFPs with discussion of potential pitfalls. The expert contributors provide real examples in showing how to tailor GFP/NFP to specific systems, maximize expression, and enhance detection.
Mentioned as the second prize area in his will, Chemistry was the most important science for Alfred Nobel's own work. The development of Nobel's inventions as well as the industrial processes he employed were based upon chemical knowledge. This volume is a collection of the Nobel lectures delivered by the prizewinners, together with their biographies and the presentation speeches for the period 2006-2010. Each Nobel lecture is based on the work for which the laureate was awarded the prize.List of prizewinners and their award citations:(2006) Roger D Kornberg — for his studies of the molecular basis of eukaryotic transcription;(2007) Gerhard Ertl — for his studies of chemical processes on solid surfaces;(2008) Osamu Shimomura, Martin Chalfie and Roger Y Tsien — for the discovery and development of the green fluorescent protein, GFP;(2009) Venkatraman Ramakrishnan, Thomas A Steitz and Ada E Yonath — for studies of the structure and function of the ribosome;(2010) Richard F Heck, Ei-ichi Negishi and Akira Suzuki — for palladium-catalyzed cross couplings in organic synthesis.