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This title in the acclaimed Blue Books of Neurology series highlights advances in epileptology and new ways of managing seizure disorders. Contributors from around the world-most new to this volume-lend a global perspective and provide the latest thinking on the new and controversial issues surrounding epilepsy. You'll find detailed discussions of difficulties in diagnosing and treating epilepsy, including the latest pharmacologic management strategies. This book covers the entire range of issues in epilepsy from basic science research to current clinical issues to medical and surgical therapeutics. Find all you need on critical issues in treating epilepsy and seizure disorders. Provides the...
This book, written by international experts in clinical epileptology and EEG, comprehensively covers the clinical and EEG features of all paediatric and adult epilepsy syndromes, as recognized by the ILAE. Each syndrome-chapter provides detailed description of the associated seizure types and the characteristic interictal findings in wakefulness and sleep, illustrated by a plethora of EEG plates. It also includes recording protocols that, adapted to available resources and complete with practical information to improve recording strategies, are designed to maximize diagnostic yield. Finally, the diagnostic confidence of the EEG report is rated according to the findings in hand and the available clinical information. A fully informative, but concise and easy-to-use, companion in the daily clinical practice for electroencephalographers and EEG technologists, but also a reference guide for epileptologists and general neurologists who care for children and adults with epilepsy.
At the Mariani Foundation meeting held in Milan, October 1995, highly qualified specialists were invited to assist in understanding of the basic principles of cerebral development and brain function, with specific attention to those structures and mechanisms involved in the phenomenon of falls. Epiliptologists illustrate the different semiologic modalities and clinical conditions in which the fall is an essential symptom. A main part of the book is dedicated to the medical and surgical treatment of syndromes where falls appear in the foreground. This volume has the mission of improving life conditions of children who suffer from drop seizures, by limiting the risks to which they are subjected, and to try and compensate for the psychological and social limitations affecting them.
An updated version of the ILAE classification and the differential diagnosis of epilepsies, written by international experts in clinical epileptology and EEG. The book covers the clinical and EEG features as well as the recording protocols of all paediatric and adult epilepsy syndromes, rates diagnostic confidence according to the findings in hand and the available clinical information. The combination of the clinical EEG information, its dynamic layout and the 150 EEGs makes this book a reference guide in daily clinical practice for all electroencephalographers, epileptologists, general and child neurologists, EEG technologists and epilepsy nurses
The present book is the fruit of a workshop, designed as a discussion forum, with the participation of experts from all over the world, to extensively review clinical, neurophysiological and fundamental research available data in order to generate new axes for research, clinical practice and care. The first section traces back to the definitions and concepts underlying the terms “generalized seizures and epilepsies”. Section II reviews human and animal data suggesting that the brainstem network plays an important role for tonic seizures generation. The third and fourth sections analyze recent knowledge on cortico-thalamic and basal ganglia networks in absence and myoclonic seizures, both in animal models and in humans. The fifth section compares the phenomenology of “Primary versus Secondary Tonico-clonic seizures”, including animal data, clinical expression in humans and genetics. Section VI goes back to the discussion “Cortical” versus “Centrencephalic” theories. The last two chapters thoroughly review the clinical applications of current knowledge, in terms of pharmacological approach and clinical care.
The boundaries between epilepsy and movement disorders are difficult to define; some syndromes or diseases may combine the two and many manifestations of one are similar to the other. For the first time, a distinguished, international team of specialists comprehensively examines the clinical, neurophysiological, genetic, pharmacological and molecular factors which underlie the relationships and differences between the two disorders. They examine the methods for investigating motor cortex excitability and the electrophysiological and chemical characteristics of epilepsies which resemble movement disorders. They present a scheme for neurophysiological classification of myoclonic epilepsies and myoclonus and give a detailed analysis of the disorders which cause diagnostic problems in children and adults. There is also an innovative, up-to-date review of the genetic syndromes which associate epilepsy and paroxysmal dyskinesias, and a review of the drugs used to treat, or which may precipitate, epilepsy and movement disorders. This is essential reading for clinicians and neuroscientists.
In the first two years of life, several important and interlinked neurological functions develop; this is a decisive developmental period. Neurological disorders arising in early childhood therefore require special attention and should be defined precisely. To be understood and managed correctly, these disorders (epilepsy, cerebral lesions, tumours, nerve damage, etc.) must be considered as a whole. By compartmentalizing the disorders and only focusing on a certain number of them, physicians run the risk of neglecting others which could have been useful in reaching a more accurate diagnosis. Written by neuropaediatricians with the aim of sharing their knowledge, this book is the only one of its kind to date to explore, in such detail, all the factors which have the potential to perturb neurological development.
This volume is the first comprehensive text and clinical reference on idiopathic myoclonic epilepsies of infancy, childhood, adolescence, and adulthood. The world’s foremost experts describe the phenotypes and subtypes of myoclonic epilepsies and the underlying molecular defects and summarize cutting-edge advances in molecular genetics that shed new light on the etiologies of these syndromes. The book offers clinicians much-needed assistance in recognizing and diagnosing idiopathic myoclonic epilepsies and selecting appropriate treatment. Each chapter includes diagnostic and treatment algorithms to guide practitioners in clinical decision making.
The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Ev...