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Case Studies in Epilepsy
  • Language: en
  • Pages: 205

Case Studies in Epilepsy

Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning - all desirable generic skills for health care professionals. Epilepsy is amongst the most frequently encountered of neurological disorders. There are important emerging clinical management issues (e.g., first seizure, therapy-resistant seizures, ICU, pregnancy) but also differential diagnosis of non-epileptic seizures (syncopy, pseudo-seizure, paroxysmal dystonic syndromes, sleep disorders, psychosis, inborn errors of metabolism, etc.). This selection of epilepsy case studies will inform and challenge clinicians at all stages in their careers. Including both common and uncommon cases, Case Studies in Epilepsy reinforces the diagnostic skills and treatment decision-making processes necessary to treat epilepsy and other seizures confidently. Written by leading experts, the cases and discussions work through differential diagnoses, treatments and social consequences in pediatric and adult patients.

Epilepsy and Movement Disorders
  • Language: en
  • Pages: 598

Epilepsy and Movement Disorders

The boundaries between epilepsy and movement disorders are difficult to define; some syndromes or diseases may combine the two and many manifestations of one are similar to the other. For the first time, a distinguished, international team of specialists comprehensively examines the clinical, neurophysiological, genetic, pharmacological and molecular factors which underlie the relationships and differences between the two disorders. They examine the methods for investigating motor cortex excitability and the electrophysiological and chemical characteristics of epilepsies which resemble movement disorders. They present a scheme for neurophysiological classification of myoclonic epilepsies and myoclonus and give a detailed analysis of the disorders which cause diagnostic problems in children and adults. There is also an innovative, up-to-date review of the genetic syndromes which associate epilepsy and paroxysmal dyskinesias, and a review of the drugs used to treat, or which may precipitate, epilepsy and movement disorders. This is essential reading for clinicians and neuroscientists.

Epileptic Syndromes in Infancy, Childhood and Adolescence - 6th edition
  • Language: en
  • Pages: 2274

Epileptic Syndromes in Infancy, Childhood and Adolescence - 6th edition

Since 1984, the year of the publication of its first edition, the famous “Blue Guide” has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents. This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases. The different backgrounds of the contributors - coordinators and authors – ensure that the book’s longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved. This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.

Dravet syndrome
  • Language: en
  • Pages: 213

Dravet syndrome

Dravet syndrome is a rare and severe type of epilepsy. “Severe myoclonic epilepsy in infancy” was first described in 1978 by Charlotte Dravet, who observed common features: onset in the first year of life, fever sensitivity, multiple seizure types, often including myoclonic seizures, and cognitive deterioration. Subsequent descriptions contributed to delineating a newly recognised epilepsy syndrome. Renzo Guerrini contributed to the knowledge of the genetic basis and response to anti epileptic drugs of Dravet syndrome. New molecules have emerged, and studies on cognitive development have qualified the impairment. Families’ associations have also contributed to a better knowledge of the...

The Causes of Epilepsy
  • Language: en
  • Pages: 1013

The Causes of Epilepsy

Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.

Oxford Textbook of Epilepsy and Epileptic Seizures
  • Language: en
  • Pages: 395

Oxford Textbook of Epilepsy and Epileptic Seizures

Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures, and is complemented by an online edition.

Progress in epileptic spasm and West syndrome
  • Language: en
  • Pages: 184

Progress in epileptic spasm and West syndrome

Since its first description (1841) the identity of West syndrome was deeply investigated and is now recognized as an epileptic syndrome in infancy (ILAE Task Force, 1989). West syndrome has become a paradigmatic model of an epileptic syndrome causing neurological deterioration (epileptic encephalopathy) and the object of a number of studies aimed at understanding the complex relationships between an epileptic disorder and neurodevelopment. Although the symptomatic triad (peculiar electrographic findings named hypsarrhythmia, brief tonic spasms, and arrest of psychomotor development) that characterizes the syndrome suggests a unique pathogenetic mechanism, causal heterogeneity heavily influen...

Pediatric Neurology Part I
  • Language: en
  • Pages: 25

Pediatric Neurology Part I

The term epileptic encephalopathy refers to the condition where epileptic activity, clinical or subclinical, is thought to be responsible for any disturbance of cognition, behavior, or motor control. Although currently described as a concept that may occur in any of the epilepsies, children with the severe early onset epilepsies are thought to be more at risk than others. These epilepsies have been termed the “epileptic encephalopathies.” The degree to which epileptic activity is responsible for neurodevelopmental compromise may be variable in each individual case, and the degree to which this may be reversible unclear. Data from the laboratory and the clinic may provide greater insight into the degree to which epileptic activity may contribute in individual syndromes, although much is yet to be learnt. The aim in epilepsy management remains one of seizure control; in some specific circumstances this may include subclinical epileptic activity. However, avoidance of treatment that may lead to deterioration of seizure control may be equally important.

Epilepsy and migraine
  • Language: en
  • Pages: 143

Epilepsy and migraine

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Pediatric Neurology Part I
  • Language: en
  • Pages: 39

Pediatric Neurology Part I

Epileptic myoclonus can be defined as an elementary electroclinical manifestation of epilepsy involving descending neurons, whose spatial (spread) or temporal (self-sustained repetition) amplification can trigger overt epileptic activity and can be classified as cortical (positive and negative), secondarily generalized, thalamo-cortical, and reticular. Cortical epileptic myoclonus represents a fragment of partial or symptomatic generalized epilepsy; thalamo-cortical epileptic myoclonus is a fragment of idiopathic generalized epilepsy. Reflex reticular myoclonus represents the clinical counterpart of fragments of hypersynchronous epileptic activity of neurons in the brainstem reticular format...