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Transient Receptor Potential Channels
Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves.
TRP Channels in Sensory Transduction
TRP channels play a key role in sensory physiology and have been the focus of intensive investigation in recent years. The proposed book will be a comprehensive, detailed overview of the ways in which TRP channels are involved in a wide variety of sensory modalities. Authors will explore the involvement of TRP channels in photo transduction (sight), chemotransduction (taste and odor), mechanotransduction (touch and hearing), thermo transduction (the sensation of temperature) and pain perception. Furthermore, the book will include some grounding chapters such as one on the history of TRP channel research, one on the biophysical characteristics of the proteins and one on trafficking and post-translational regulation.
New Research on Signal Transduction
In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. In such cases the chain of steps is referred to as a "signalling cascade" or a "second messenger pathway" and often results in a small stimulus eliciting a large response. Hormones and other signalling molecules may exit the sending cell by exocytosis or other means of membrane transport. The sending cell is typically of a specialised type. Its recipients may be of one type or several, as in the case of insulin, which triggers diverse and systemic effects. This book sheds new light in this exciting field of cell transportation research.
Sensing with Ion Channels
This is the first book that is not exclusively focused on ion channels functioning in sensory mechanisms that are characteristic of animals and humans, but also describes the role of ion channels in signal transduction mechanisms found in microbial cells and plants. It summarizes comprehensively the progress that has been made in studies of ion channels and their role in sensory physiology.
The Weight of Blood
'It is a long time since I have read a debut as impressive as Laura McHugh's The Weight of Blood. It is a chilling portrait of a small town in the Ozarks where violent men are protected and young women vanish.' Joan Smith, The Sunday Times People still whisper about Lucy Daneâe(tm)s mother who vanished years ago from the town of Henbane, deep in the Ozark mountains. When one of Lucyâe(tm)s friends is found murdered, Lucy feels haunted by the two lost women: by the mother she never knew, and the friend she couldnâe(tm)t protect. But her search for answers, in a place where secrets are easily concealed, leads her to a chilling discovery. And with this revelation, she must grapple with the meaning of family, the secrets we keep, and the lengths we will go to protect the ones we love.
Vascular Ion Channels in Physiology and Disease
Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.
The Magic of Magus: Magus and the Navaratna
The Magic of Magus: The World’s Most Diverse Story is a series of 13 books about fantasy, magic, mythology, and space. Book 1: Magus and the Navaratna Imagine waking up one morning to find yourself in the midst of a mystery. Eighteen 18-year-olds from around the world, each with their unique cultural backgrounds and perspectives, experienced just that. They were approached by three enigmatic professors from Maguš, a mysterious institution, who asked about their dreams before disappearing without a trace. Later, they were informed of a generous anonymous benefactor who would support their pursuit of a Bachelor of Magic degree alongside a conventional degree of their choice at Maguš Univer...
