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Signal Transduction in Testicular Cells
This book features selected aspects of the molecular endocrinology of the testis with specific emphasis on signal transduction and gene regulation. Each chapter is written by internationally recognized authorities. Covering both basic research and clinical andrology, the book presents subjects as hormonal gene regulation and post-meiotic gene expression. Molecular endocrinology and pathophysiology of GnRH deficiency and the LH and FSH receptors are presented. Components of cyclic nucleotide-dependent signalling systems are discussed. Furthermore, regulation and pathophysiology of steroidogenesis and androgen action are presented, as well as tyrosine kinase-mediated signalling in germ cells and sperm. Finally, research in andrology and novel methods for in vitro fertilization are discussed.
Gonadotropin-Releasing Hormone: Molecules and Receptors
This volume summarizes the evolution and physiology of GnRH molecules and receptors, and provides insight as to how social behavior influences cellular and molecular events in the brain from a comparative perspective.The chapters in this volume are divided into three major sections: Development and Cell Migration, GnRH Receptors, Physiology and Regulation. The review papers arose primarily from presentations made at the Second International Symposium on the Comparative Biology of GnRH, held in Penang, Malaysia, June 2-4, 2001; a satellite symposium in conjunction with the XIV International Congress of Comparative Endocrinology, Sorrento, Italy. In addition, leading neuroscientists doing cutting-edge research in the field of GnRH were invited as authors to make this volume a valuable reference.
Medical Therapy in Urology
The future of urology is changing from one based around surgery, to an outpatient system, concentrating mainly on medical mana- ment. Last year, in the UK, there were almost two million hospital consultations for urological symptoms and an estimated fve million consultations in general practice. With such a signifcant proportion of care being delivered for urology, 80% of which can be managed medically, we felt that a resource should be made available to providers that will serve as a quick and useful guide to the medical management of urological disease. The aim was to provide a fresh, practical, and concise overview of the key medical management issues every practicing clinician faces in a...
Circulating Regulatory Factors and Neuroendocrine Function
During the past several decades, much research effort has gone into the elucidation of the role of neuroendocrine systems as secretory and metabolic regulators of cells of a variety of organs and structures, including the testes, ovaries, adrenals, thyroid, pituitary gland, and mammary glands. However, the role of cells comprising such organs and structures in the modulation of neuroendocrine processes has received considerably less is generally less well appreciated. attention and Nonetheless, it is important that we understand the actions on neuroendocrine systems of substances that reach the brain by way of the vasculature, including hormones, cytokines, toxins, amino acids, drugs, and si...
Stress Science
Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that explains the phenomenon of stress, the neural, endocrine and molecular mechanisms involved, the clinical effects, and the impact on individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing's Syndrome: Addison's Disease) and the adverse impact of stress on human physical and mental health . Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as...
Clinical Neuroembryology
This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube d...
The Kidney
Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney. - Hundreds of color figures depicting key events in all aspects of kidney development - Full coverage of the genetic and cellular basis of kidney development - Analysis of the genetic basis of the major congenital kidney diseases
Handbook of Neuroendocrinology
Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
Endocrine Pathology:
Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition provides detailed coverage of endocrine pathology with extensive discussion of the differential diagnosis as well as presentation of molecular pathobiology of the major endocrine organs. Revised and expanded from the first edition, each chapter, written by leaders in their respective field, has been updated with the latest advances that are transforming the field of endocrine pathology. Richly illustrated with color photomicrographs, useful diagrams and line drawings, each chapter includes differential diagnosis of common and uncommon lesions as well as material on molecular developments, with emphasis on the molecular findings that are most helpful in the diagnosis of specific disorders. Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition, provides a useful and well-organized resource designed not only for the endocrine pathologist and the general surgical pathologist, but also for the clinical endocrinologist and the endocrine surgeon.
Opioid Peptides and Blood Pressure Control
This book provides current knowledge on the influence of endogenous opioid peptides on blood pressure regulation. In view of the rapid increase in knowledge in the field, it is important that scientists in blood pressure research as well as specialist clinicians have access to such a comprehensive survey. The book is divided into sections on neuroanatomy, where both the central and peripheral nervous systems are considered; on physiology and pharmacology, whereby experiments with intact animals as well as with histologic preparations are described; and on clinical questions, where examinations of normotensive and hypertensive patients as well as experiments on the influence of various drugs are emphasized. The contributions are presented in the form of reviews and single articles which allow the reader to obtain a clear and detailed survey of a range of highly topical subjects.
