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Signal Transduction in Testicular Cells
This book features selected aspects of the molecular endocrinology of the testis with specific emphasis on signal transduction and gene regulation. Each chapter is written by internationally recognized authorities. Covering both basic research and clinical andrology, the book presents subjects as hormonal gene regulation and post-meiotic gene expression. Molecular endocrinology and pathophysiology of GnRH deficiency and the LH and FSH receptors are presented. Components of cyclic nucleotide-dependent signalling systems are discussed. Furthermore, regulation and pathophysiology of steroidogenesis and androgen action are presented, as well as tyrosine kinase-mediated signalling in germ cells and sperm. Finally, research in andrology and novel methods for in vitro fertilization are discussed.
Cellular Regulation of Secretion and Release
Cellular Regulation of Secretion and Release is a compilation of papers that deals with the processes in cellular perception of stimuli and the response to them. Part I describes the receptor occupancy and regulation of stimulus through the use of video image intensification techniques. This part also explains a model for the transmembrane regulation of adenylate cyclase that shows the mechanisms that cells use in sensing and responding to extracellular conditions. Part II discusses the early responses of secretory cells including changes in phospholipid metabolism, in electrophysiological events, and in macromolecular carboxymethylation. One paper suggests that protein-carboxyl methylase ha...
Proceedings
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House documents
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Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Research on Steroids
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The Natural and Societal Challenges of the Northern Sea Route
Yohei Sasakawa The Northern Sea Route is the shortest shipping route connecting the Far East and Europe. However, the route has been practically inaccessible to commercial vessels, due to the harsh natural conditions in the area, which make navigation possible for only a small part of the year, and then only with an icebreaker leading the way. Opening the Northern Sea Route would greatly facilitate international shipping, making two routes - a northbound one through the NSR, and a southbound one through Suez- available throughout all seasons. The Northern Sea Route would also help to boost economic development, including the exploitation of natural resources in Russian regions along the coast of the Arctic Ocean. Thanks to international cooperation, we have been able to set up and successfully conclude a special project to investigate the possibilities of developing the Northern Sea Route as a commercial route, while protecting the environment, wildlife and peoples of the Arctic Ocean region. This represents a highly significant step in terms of future global development.
