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The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes.System...
Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems. Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of th...
Pathway Design for Industrial Fermentation Explore the industrial fermentation processes of chemical intermediates In Pathway Design for Industrial Fermentation, distinguished researcher Dr. Walter Koch delivers an expert overview on industrial fermentation production technology as compared with natural extraction, organic chemistry, and biocatalysis. The book offers key insights for professionals designing and monitoring fermentation processes. The author explores the applications, alternative production, biochemical pathways, metabolic engineering strategy, and downstream processing of various products—including C1 to C6 products—with a focus on low-value products with market prices be...
The International Symposium on Distributed Computing and Artificial Intelligence 2012 (DCAI 2012) is a stimulating and productive forum where the scientific community can work towards future cooperation in Distributed Computing and Artificial Intelligence areas. This conference is a forum in which applications of innovative techniques for solving complex problems will be presented. Artificial intelligence is changing our society. Its application in distributed environments, such as the internet, electronic commerce, environment monitoring, mobile communications, wireless devices, distributed computing, to mention only a few, is continuously increasing, becoming an element of high added value...
This book constitutes the refereed proceedings of the 14th International Conference on Verification, Model Checking, and Abstract Interpretation, VMCAI 2013, held in Rome, Italy, in January 2013, co-located with the Symposium on Principles of Programming Languages, POPL 2013. The 27 revised full papers presented were carefully reviewed and selected from 72 submissions. The papers cover a wide range of topics including program verification, model checking, abstract interpretation and abstract domains, program synthesis, static analysis, type system, deductive methods, program certification, debugging techniques, program transformation, optimization, hybrid and cyber-physical systems.
This book constitutes the refereed proceedings of the First International Bioinformatics Research and Development Conference, BIRD 2007, held in Berlin, Germany in March 2007. The 36 revised full papers are organized in topical sections on microarray and systems biology and networks, medical, SNPs, genomics, systems biology, sequence analysis and coding, proteomics and structure, databases, Web and text analysis.
The current advances in sequencing, data mining, DNA synthesis, cloning, in silico modeling, and genome editing have opened a new field of research known as Synthetic Genomics. The main goal of this emerging area is to engineer entire synthetic genomes from scratch using pre-designed building blocks obtained by chemical synthesis and rational design. This has opened the possibility to further improve our understanding of genome fundamentals by considering the effect of the whole biological system on biological function. Moreover, the construction of non-natural biological systems has allowed us to explore novel biological functions so far not discovered in nature. This book summarizes the current state of Synthetic Genomics, providing relevant examples in this emerging field.
This book is a printed edition of the Special Issue "Biological Networks" that was published in Processes
Increased consumption of electronic equipment has brought with it a greater demand for rare earth elements and metals. Adding to this is the growth in low carbon technologies such as hybrid fuel vehicles. It is predicted that the global supply of rare earth elements could soon be exhausted. A sustainable approach to the use and recovery of rare earth elements is needed, and this book addresses the political, economic and research agendas concerning them. The problem is discussed thoroughly and a multi-disciplinary team of authors from the chemistry, engineering and biotechnology sectors presents a range of solutions, from traditional metallurgical methods to innovations in biotechnology. Case studies add value to the theory presented, and indirect targets for recovery, such as municipal waste and combustion ash are considered. This book will be essential reading for researchers in academia and industry tackling sustainable element recovery, as well as postgraduate students in chemistry, engineering and biotechnology. Environmental scientists and policy makers will also benefit from reading about potential benefits of recovery from waste streams.