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Multi-omic Data Integration
Stable, predictive biomarkers and interpretable disease signatures are seen as a significant step towards personalized medicine. In this perspective, integration of multi-omic data coming from genomics, transcriptomics, glycomics, proteomics, metabolomics is a powerful strategy to reconstruct and analyse complex multi-dimensional interactions, enabling deeper mechanistic and medical insight. At the same time, there is a rising concern that much of such different omic data –although often publicly and freely available- lie in databases and repositories underutilised or not used at all. Issues coming from lack of standardisation and shared biological identities are also well-known. From thes...
Logical Modeling of Cellular Processes: From Software Development to Network Dynamics
Mathematical models have become invaluable tools for understanding the intricate dynamic behavior of complex biochemical and biological systems. Among computational strategies, logical modeling has been recently gaining interest as an alternative approach to address network dynamics. Due to its advantages, including scalability and independence of kinetic parameters, the logical modeling framework is becoming increasingly popular to study the dynamics of highly interconnected systems, such as cell cycle progression, T cell differentiation and gene regulation. Novel tools and standards have been developed to increase the interoperability of logical models, which can now be employ to respond a variety of biological questions. This Research Topic brings together the most recent and cutting-edge approaches in the area of logical modeling including, among others, novel biological applications, software development and model analysis techniques.
Computational Intelligence Methods for Bioinformatics and Biostatistics
This book constitutes the thoroughly refereed post-conference proceedings of the 13th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2016, held in Stirling, UK, in September 2016. The 19 revised full papers and 6 keynotes abstracts presented were carefully reviewed and selected from 61 submissions. The papers deal with the application of computational intelligence to open problems in bioinformatics, biostatistics, systems and synthetic biology, medicalinformatics, computational approaches to life sciences in general
Computational Intelligence Methods for Bioinformatics and Biostatistics
This book constitutes the thoroughly refereed post-conference proceedings of the 15th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics., CIBB 2018, held in Caparica, Portugal, in September 2018. The 32 revised full papers were carefully reviewed and selected from 51 submissions. The papers present current trends at the edge of computer and life sciences, the application of computational intelligence to a system and synthetic biology and the consequent impact on innovative medicine were presented. Theoretical and experimental biologists also presented novel challenges and fostered multidisciplinary collaboration aiming to blend theory and practice, where the founding theories of the techniques used for modelling and analyzing biological systems are investigated and used for practical applications and the supporting technologies.
In Silico Immunology
This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.
Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response (volume I.C)
Volume I.C An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international ...
Encyclopedia of Bioinformatics and Computational Biology
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major ref...
The Wiley Blackwell Companion to Medical Sociology
A comprehensive collection of original essays by leading medical sociologists from around the world, fully updated to reflect contemporary research and global health issues The Wiley Blackwell Companion to Medical Sociology is an authoritative overview of the most recent research, major theoretical approaches, and central issues and debates within the field. Bringing together contributions from an international team of leading scholars, this wide-ranging volume summarizes significant new developments and discusses a broad range of globally-relevant topics. The Companion's twenty-eight chapters contain timely, theoretically-informed coverage of the coronavirus pandemic and emerging diseases, ...
Systems Medicine
Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling...
Life-Span Extension
In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and...
