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Cardiovascular Proteomics
This cutting-edge book presents protocols and strategies for proteomic evaluation of cardiovascular disease written by pioneering researchers in the field. Topics explored in this comprehensive volume include obtaining specific heart proteins, techniques for identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, and phage display techniques for deciphering the molecular diversity of blood vessels.
10 Years of Inflammation Pharmacology
The past and future of inflammatory pharmacology research: a hot topic in health and disease Inflammation is a physiological response to a traumatic injury, bacterial, or viral infection. However, if not appropriately controlled, it contributes to a long list of diseases, including asthma, atherosclerosis, multiple sclerosis, arthritis, and cancer. Different are the types of inflammatory responses. Acute inflammation is an immediate body response to the cellular damage induced by pathogens, noxious stimuli, or physical injury – it is a short-term response resulting in healing via time-dependent changes of leukocyte functions. First, a leukocytes infiltration happens within the damaged regi...
AI in Clinical Medicine
AI IN CLINICAL MEDICINE An essential overview of the application of artificial intelligence in clinical medicine AI in Clinical Medicine: A Practical Guide for Healthcare Professionals is the definitive reference book for the emerging and exciting use of AI throughout clinical medicine. AI in Clinical Medicine: A Practical Guide for Healthcare Professionals is divided into four sections. Section 1 provides readers with the basic vocabulary that they require, a framework for AI, and highlights the importance of robust AI training for physicians. Section 2 reviews foundational ideas and concepts, including the history of AI. Section 3 explores how AI is applied to specific disciplines. Section...
Adverse outcomes of preeclampsia: From mother to baby, pregnancy to postpartum
Preeclampsia poses severe risks on both mother and baby during pregnancy. A large body of evidence now indicates that a history of preeclampsia also increases the risk of disease well beyond the index pregnancy. Studies show that mothers are at increased risk of cardiovascular, renal and neurological diseases. Babies are at increased risk of cardiovascular disease, obesity, neurodevelopmental impairments and mental health disorders, across childhood, adolescence and adulthood. There is critical importance in understanding the pathophysiology of these outcomes to uncover appropriate therapeutic targets.
Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases
It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found i...
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