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Moira Keegan is certain that someone is trying to kill her father. She tries to recruit Sherlock Holmes to save his life, but all at 221B Street are certain that there is no basis for Moira's fears. When, a short time later, they read of the man's death in a sleazy waterfront inn, the members of London's premier consulting detective agency have a new client and a singular purpose. Their investigation will place them at odds with Scotland Yard's Special Branch, Irish revolutionaries, religious zealots, and even staff of the London Times. Only Lestrade remains an ally, and he dare only participate covertly with his frequent colleagues. Before all can be brought right, the Baker Street trio will have to call on the assistance of Charles Stewart Parnell, leader of the Irish Parliamentary Party, and his mistress Katharine O'Shea.
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How the FDA was shaped by public health crises and patient advocacy, told against a background of the contentious hearings on the breast cancer drug Avastin. Food and Drug Administration approval for COVID-19 vaccines and the controversial Alzheimer’s drug Aduhelm made headlines, but few of us know much about how the agency does its work. Why is the FDA the ultimate US authority on a drug’s safety and efficacy? In Drugs and the FDA, Mikkael Sekeres—a leading oncologist and former chair of the FDA’s cancer drug advisory committee—tells the story of how the FDA became the most trusted regulatory agency in the world. It took a series of tragedies and health crises, as well as patient ...
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Contains contact information and biographical sketches about the members of the United States Congress.
Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the marketplace, and expand the horizon of contemporary thinking about cancer biology. A poorly done trial does little to advance the field or guide clinical practice, consumes precious clinical and financial resources and challenges the validity of the ethical contract between investigators and the volunteers who willingly give their time and effort to benef...
The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research.