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The increase in the prevalence of diet-related diseases in the female population since the second half of the 20th century is likely the result of increasing life expectancy combined with increased exposure to environmental factors, including lifestyle. To date, the exact mechanism for the development of many nutrition-related diseases remains unknown. Mainly because of the multifactorial etiology. It is often forgotten that human biology and pathophysiology are regulated at the level of gene expression. "Genetics loads the gun, but the environment pulls the trigger" by Judith Stern illustrates the complex relationship between diseases and environmental factors. The analogy accurately conveys that disease phenotypes are not only the result of interactions between different genes but also between genes and environmental determinants.
This timely Research Handbook examines sport-related research and analysis pertaining to how the sport industry has been impacted by the Covid-19 pandemic. Taking stock of the changes over the course of the pandemic, it also provides key insights into how the sport industry and its stakeholders might move forward in post-pandemic times.
The year 2019 has been prolific in terms of new evidence regarding the effects of coffee and caffeine consumption on diverse aspects of human functioning. This book collects 20 high-quality manuscripts published in Nutrients that include original investigation or systematic review studies of the effects of caffeine intake on human performance and health. The diversity of the articles published in this Special Issue highlights the extent of the effects of coffee and caffeine on human functioning, while underpinning the positive nature of most of these effects. This book will help with understanding why the natural sources of caffeine are so widely present in the nutrition behaviors of modern society.
The book contains recent research about physiology, psychology, nutrition and training aspects of Marathon Running of different age, gender and performance level. The basic knowledge of marathon running with explanations of the physiological and psychological mechanisms induced by marathon training with the associated adaptations and subsequent improved physiological capacities are presented in a reader friendly format for researchers and practitioners. The book includes a full range of useful practical knowledge, as well as trainings principles to guide the reader to run marathon faster. After reading the book the reader is able to develop training plans and owns the knowledge about up-to-date scientific results in the fields of physiology, psychology, nutrition in marathon running.
Immunotherapy with genetically engineered immune cell products is a transformative treatment modality with potential applications in various fields of medicine. A prime example is chimeric antigen receptor (CAR)-modified T cells in hematology and oncology, and the advent of CAR T cell therapies to treat infectious diseases, autoimmune disorders, and cardiovascular diseases. The medical need and demand from patients and caregivers require radical innovations to accelerate and improve pre-clinical development and clinical translation, provision of gene-transfer vectors, and immune cell product manufacturing as well as a critical reflection and discussion on ethical and socioeconomic aspects. T...
Rociana, Memorias de los sesenta y setenta. Son nuestras memorias, de aquella generación de los años sesenta y setenta del pasado siglo XX, en toda España, más concreto en la Andalucía Occidental, que es donde se desarrolla estas vivencias y recuerdos de un pasado reciente. Seguro se sentirán identificados con lo que voy a narrar en este primer libro. No eran los mejores tiempos para nuestras familias, padre y abuelos que sufrieron en un país atrasado que remontaba lentamente para salir de una extrema pobreza de la interminable posguerra de los años cuarenta y cincuenta. Tenemos retenido recuerdos que afloran cuantos más años pasan por nuestras vidas. A veces lo tenemos tan present...