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Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
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The prodigious but humble scion of a New York theatrical family, Chester Morris acted on Broadway as a teenager and earned an Academy Award nomination for his first role in a Hollywood "talkie," Alibi (1929). He became leading man to filmdom's top female stars and starred in the popular series of "Boston Blackie" mysteries before creating substantial characters in the theater and the burgeoning medium of television. This first book about Morris provides a detailed account of his life and career on stage, film, radio and television, and as a celebrated magician. It also constructs a fascinating record of his previously undocumented labor activism during the early years of the Screen Actors Guild and his tireless efforts to aid U.S. troops on the home front during World War II.
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