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In the world of drug design and development, Paul Janssen was a giant - responsible for over 80 new medicines in his lifetime. He was the founder of Janssen Pharmaceutica which later merged with Johnson & Johnson. This is the story of his success in building a pharmaceutical 'empire' in China at a time when the country was essentially closed to the west. A fascinating story of remarkable individuals, of business deals and scientific research, of international politics and cultural change, of humanity and ambition.
Readers will find in the pages of this book a treatment of the statistical analysis of clustered survival data. Such data are encountered in many scientific disciplines including human and veterinary medicine, biology, epidemiology, public health and demography. A typical example is the time to death in cancer patients, with patients clustered in hospitals. Frailty models provide a powerful tool to analyze clustered survival data. In this book different methods based on the frailty model are described and it is demonstrated how they can be used to analyze clustered survival data. All programs used for these examples are available on the Springer website.
From New York Times bestseller Judith Michael comes a dramatic novel of love, loss, and deep-buried family secrets. Laura Fairchild enters a charmed world when eccentric patriarch Owen Salinger takes her in as his protegee and confidante. In the patrician circles of Boston’s Beacon Hill, she acquires grace, culture, and a passionate lover in Owen’s nephew, Paul. But Owen’s death shatters her dreams. Favored in his will, she now faces the wrath of his family, who close ranks against her. Disinherited, Laura vows to recapture all that has been ruthlessly taken away. With brilliance and flair she builds a hotel empire. Yet beneath her successful facade lives the outcast girl, longing for the home and family she has lost. As long-buried secrets rise like threatening clouds, Laura has to fight to regain her love, her family, and to claim her true inheritance!
In this book Paul Janssen describes the various models of psychoanalytic and group analytic in-patient psychotherapy. After focusing on his own integrative model he goes on to explain in what circumstances in-patient groups are effective
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contribut...
A catch phrase is a well-known, frequently-used phrase or saying that has `caught on' or become popular over along period of time. It is often witty or philosophical and this Dictionary gathers together over 7,000 such phrases.
Published since 1959, this serial presents in-depth reviews on key topics in neuroscience, from molecules to behavior. The serial stays keenly attuned to recent developments in the field through the contributions offirst-class experts. Neuroscientists as well as clinicians, psychologists, physiologists, and pharmacologists will find this serial an indispensable addition to their library.