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A NATO Advanced Study Institute on "New Developments in Lipid-Protein Interactions and Receptor Function" was held on the Island of Spetsai, Greece, from August 16-27, 1992. This Institute was organized to bring together researchers in the field of membrane organization and dynamics with those actively involved in studies on receptor function, signal transduction mechanisms and gene regulation. 2 Presentations and discussions focussed on the regulation of intracellular Ca +-levels, on the second messengers derived from inositol lipids and on the specific phospholipase C isozymes involved in these processes. A major focus was on G-proteins and the effect of lipid anchors on their function. Th...
This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues. The number of clearly identifiable and distinct disorders has grown somewhat since the 1st edition in 2014, e.g., Ehlers-Danlos syndrome has now 13 entities. A brand new syndrome, Meester Loeys syndrome carrying the name of Bart Loeys was added as a companion to Loeys-Dietz syndrome. Numerous variations of cutis laxa and joint mobility disorders have been discovered taking advantage of recent advancements in genetic analysis. We have acquired better understanding of pathogene...
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Spoken Language Comprehensionis the first coherent presentation of an original detailed experimental and theoretical account of what are rationally taken to be "online" processing deficits that lie at the core of aphasic miscomprehension. It presents exciting work that is highly relevant to the important current debate about the nature of aphasic comprehension impairment and its relationship to models of normal functioning. Lorraine K. Tyler focuses on a crucial but neglected aspect of language disorders: how the real-time analysis processes involved in comprehending spoken language break down in acquired aphasia. She describes a new approach to the study of language disorders that specifies...
Child protection and family support is a major social issue and there is a continuing debate about how policies and practices in relation to child protection integrate with those in family support and child welfare more generally. Prompted in part by the Audit Commission and the publication of the Department of Health Research studies in Child Protection, it is the key issue facing all child welfare agencies. While it is agreed that there needs to be a rebalancing between child protection and family support there is a real fear amongst managers and practitioners if things go wrong, subjecting them to public inquiry and media contempt. Child Protection and Family Support brings together a range of distinguished researchers and commentators to analyze the nature of the issue and possible ways forward. It draws on recent research case studies; policy makers, managers and practitioners in social work and child welfare agencies.
Guide to advances in diagnosis and treatment of head and neck cancers over last century. Led by New York specialist, numerous experts provide commentary on 100 contributory articles.