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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Bcl-2 proteins are very well known regulators of the programmed cell death. Accumulating evidence suggests that they are also involved in regulation of calcium signalling events. Bcl-2 has been reported to affect calcium release from the intracellular calcium stores through regulation of inositol trisphosphate receptors and endoplasmic reticulum calcium pumps. Physiological and pathological processes in pancreatic acinar cells are controlled by calcium. Intracellular Ca2+ signals regulate not only gene expression and trigger enzyme secretion but also might contribute to premature trypsinogen activation and development of pancreatitis, which is characterised by extensive necrosis of the pancr...
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Vols. 36- include Proceedings of the Biochemical Society.
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