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CARMA Proteins: Playing a Hand of Four CARDs
Some twenty years ago, the search began for B-cell lymphoma (BCL)-10 binding partners that connect via homophilic interaction with its N-terminal caspase recruitment domain (CARD) to induce nuclear factor-kappa B (NF-κB) activation. This effort led first to the identification of the protein CARD9. Soon afterwards, similar searches identified CARD10 (aka CARMA3), CARD11 (aka CARMA1) and CARD14 (aka CARMA2), as further BCL10 interactors. These discoveries paved the way for landmark progress in our understanding of NF-κB activation pathways downstream of several cell surface receptors on multiple cell types, focused particularly on antigen receptors on lymphocytes. An additional binding partn...
História da Filosofia Ocidental
Alguns filósofos contemporâneos podem ter pouco interesse na religião, mas praticamente todos os grandes pensadores dos mundos europeu antigo, medieval e moderno eram intensamente interessados em questões sobre Deus e realidades espirituais. Uma história da Filosofia que negligencie esse fato será uma história mais pobre, assim como uma história da Filosofia que negligencie as conexões entre Filosofia e desenvolvimentos científicos seria uma história mais pobre. História da Filosofia Ocidental, de C. Stephen Evans, é uma obra monumental que guia o leitor através dos labirintos do pensamento filosófico desde os primeiros pré-socráticos até os complexos debates do pós-modern...
OECD Public Governance Reviews The Innovation System of the Public Service of Brazil An Exploration of its Past, Present and Future Journey
Governments must innovate if they are to be effective. In a world of change, a government that stands still will soon be overtaken by events and shifting citizen expectations. This report explores the past, present and possible future journey of the innovation system of the Brazilian public service.
Annual Report
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Democratic Brazil
After 21 years of military rule, Brazil returned to democracy in 1985. Over the past decade and a half, Brazilians in the Nova Repœblica (New Republic) have struggled with a range of diverse challenges that have tested the durability and quality of the young democracy. How well have they succeeded? To what extent can we say that Brazilian democracy has consolidated? What actors, institutions, and processes have emerged as most salient over the past 15 years? Although Brazil is Latin America's largest country, the world's third largest democracy, and a country with a population and GNP larger than Yeltsin's Russia, more than a decade has passed since the last collaborative effort to examine ...
Flowering Plants. Eudicots
This volume, the tenth in the series, comprises modern treatments for the families and genera of the eudicot orders Sapindales and Cucurbitales. The circumscription of the orders, families and genera conforms to the most recent systematic studies. The family treatments include descriptions of the families and the genera, genera classification keys, discussions of relationships and data on their morphology, reproductive biology, distribution, ecology and economic importance. Sapindales and Cucurbitales, as understood in this volume, comprise 16 families with 637 genera and roughly 9,240 species. Sapindales include large tropical and southern temperate tree families such as the Anacardiaceae, ...
Occupational Safety and Hygiene IV
Occupational Safety and Hygiene IV covers a wide variety of topics, including but not limited to:- Occupational Safety- Risk Assessment- Ergonomics- Management Systems- Physical Environment - Construction Safety, and - Human FactorsThis compilation of papers in the domain of occupational safety and hygiene is mainly based on research works carried
