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Chemical Biology of Neurodegeneration
  • Language: en
  • Pages: 378

Chemical Biology of Neurodegeneration

Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective ...

Chemical Synthesis of Nucleoside Analogues
  • Language: en
  • Pages: 859

Chemical Synthesis of Nucleoside Analogues

Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiom...

Building the Future Internet through FIRE
  • Language: en
  • Pages: 792

Building the Future Internet through FIRE

The Internet as we know it today is the result of a continuous activity for improving network communications, end user services, computational processes and also information technology infrastructures. The Internet has become a critical infrastructure for the human-being by offering complex networking services and end-user applications that all together have transformed all aspects, mainly economical, of our lives. Recently, with the advent of new paradigms and the progress in wireless technology, sensor networks and information systems and also the inexorable shift towards everything connected paradigm, first as known as the Internet of Things and lately envisioning into the Internet of Everything, a data-driven society has been created. In a data-driven society, productivity, knowledge, and experience are dependent on increasingly open, dynamic, interdependent and complex Internet services. The challenge for the Internet of the Future design is to build robust enabling technologies, implement and deploy adaptive systems, to create business opportunities considering increasing uncertainties and emergent systemic behaviors where humans and machines seamlessly cooperate.

A Bishopric Between Three Kingdoms
  • Language: en
  • Pages: 305

A Bishopric Between Three Kingdoms

  • Type: Book
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  • Published: 2011-08-25
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  • Publisher: BRILL

This book explores the peculiarities of the Bishopric of Calahorra’s eleventh- and twelfth-century institutional development, and their profound relationship to the see’s location on a highly volatile frontier between the emergent and fiercely competitive Christian kingdoms of north-eastern Iberia.

Model Checking Software
  • Language: en
  • Pages: 285

Model Checking Software

  • Type: Book
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  • Published: 2007-08-30
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  • Publisher: Springer

This book presents the proceedings of the 14th International SPIN workshop on Model Checking Software, held in Berlin, Germany. Fourteen full papers are presented, together with four tool presentation papers and the abstracts of two invited talks. The papers are organized into topical sections covering directed model checking, partial order reduction, program analysis, exploration advances, modeling and case studies, and tool demonstrations.

Actas de Las VIII Jornadas de Concurrencia
  • Language: en
  • Pages: 354

Actas de Las VIII Jornadas de Concurrencia

La proliferación actual de sistemas concurrentes, en general debido al abaratamiento sustancial de poderosos sistemas de cómputo, y el auge, cada vez mayor, que toman las aplicaciones distribuidas, hace que cada vez sea más interesante el estudio de los sistemas concurrentes en todos los aspectos de la Informática. La mayor complejidad y tamaño de los secuenciales convencionales exige el uso de técnicas adecuadas tanto para su diseño y análisis, como para su posterior implementación práctica. Este libro contiene las comunicaciones que han sido presentadas en la Octava edición de las Jornadas de Concurrencia, celebradas en Cuenca en junio de 2000. Este es un foro para el intercambio de experiencias entre los investigadores nacionales tanto de la Universidad como de la Industria en el campo de los sistemas concurrentes, y por tanto en él se muestran tanto los resultados teóricos como las aplicaciones industriales más recientes en esta materia.

Theoretical and Practical Aspects of SPIN Model Checking
  • Language: en
  • Pages: 282

Theoretical and Practical Aspects of SPIN Model Checking

  • Type: Book
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  • Published: 2003-05-21
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  • Publisher: Springer

Increasing the designer’s con dence that a piece of software or hardwareis c- pliant with its speci cation has become a key objective in the design process for software and hardware systems. Many approaches to reaching this goal have been developed, including rigorous speci cation, formal veri cation, automated validation, and testing. Finite-state model checking, as it is supported by the explicit-state model checkerSPIN,is enjoying a constantly increasingpopularity in automated property validation of concurrent, message based systems. SPIN has been in large parts implemented and is being maintained by Gerard Ho- mann, and is freely available via ftp fromnetlib.bell-labs.comor from URL ht...

New York Supreme Court Appellate Division First Department
  • Language: en
  • Pages: 948

New York Supreme Court Appellate Division First Department

  • Type: Book
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  • Published: Unknown
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  • Publisher: Unknown

None

Journal
  • Language: en
  • Pages: 1039

Journal

  • Type: Book
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  • Published: 1885
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  • Publisher: Unknown

None

Appendix to the Journals of the Senate and Assembly ... of the Legislature of the State of California ...
  • Language: en
  • Pages: 1058