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This book provides a multidisciplinary review of antibiotic resistance and unravels the complex and interrelated roles of environmental sources, including pharmaceutical industry effluents, hospital and domestic effluents, wildlife and drinking water. Antibiotic resistance is a global public health issue in which the interface between humans, animals and the environment is particularly relevant. The contrasts seen across different environmental compartments and world regions, which are due to climate, social and policy differences, mean that this problem needs to be analyzed from a multi-geographic and multi-cultural angle. Bringing together contributions from researchers on different continents with expertise in antibiotic resistance in a range of different environmental compartments, the book offers a detailed reflection on the paths that make antibiotic resistance a global threat, and the state-of- the-art in antibiotic resistance surveillance and risk assessment in complex environmental matrices.
Background Bacteria use quorum sensing (QS) circuits to coordinate various activities (among which biofilm formation and the expression of virulence factors) based on the presence of signaling molecules. Different families of signal molecules have been identified in Gram positive and Gram negative bacteria (e.g. autoinducer peptides and acyl homoserine lactones). Similarly, different quorum sensing antagonists interfering with these system have been found in nature, promoting a new and promising field of research, quorum sensing interference. One of the most intensively studied applications of quorum sensing interference is its use as an alternative or synergycally with antibiotics to fight ...
As more countries become water-scarce, alternative water sources like treated wastewaters will be used to meet the demands of the domestic, agriculture and industrial sectors. However, the use of treated wastewater is only justified when it is without any detrimental impacts on public health, food safety and water quality. To minimize impacts, well-operated treatment plants are important barriers that reduce the amount of contaminants disseminated from wastewaters into the environment during reuse events. Continuous, accurate and comprehensive monitoring on our water further safeguards the public against potential risks. This eBook looks into topics that close the knowledge gaps in these mentioned areas.
This Special Issue on Antimicrobial Resistance in Environmental Waters features 11 articles on the monitoring and surveillance of antimicrobial resistance (AMR) in natural aquatic systems (i.e., reservoirs, rivers), and effluent discharge from water treatment plants to assess the effectiveness of AMR removal and resulting loads in treated waters. Some of the key elements of AMR studies presented in this Special Issue highlight the underlying drivers of AMR contamination in the environment and the evaluation of the hazard imposed on aquatic organisms in receiving environments through ecological risk assessments. As described in this Issue, screening antimicrobial peptide (AMP) libraries for biofilm disruption and antimicrobial candidates are promising avenues for the development of new treatment options to eradicate resistance.
Antimicrobial resistance (AMR) has been recognized as one of the greatest global threats to humans, animals, plants and ecosystems health threatening the achievement of the Sustainable Development Goals. In our globally connected world, resistance to antimicrobials may spread and circulate among humans, animals, plants and the environment, necessitating a “One Health” approach. While the One Health approach is relevant to all efforts to prevent and control AMR, this priority research agenda focuses on research areas at the interface between sectors. This research agenda is a joint product of the Quadripartite organizations –FAO, UNEP, WHO and WOAH - and a result of extensive stakeholde...
Rivers, lakes and the ocean receive antibiotic resistance genes from human environments. The aquatic environments are a huge reservoir and exchange stage of antibiotic resistance genes.
This book provides a broad and nuanced overview of the achievements and legacy of Professor William (“Bill”) Goddard in the field of computational materials and molecular science. Leading researchers from around the globe discuss Goddard’s work and its lasting impacts, which can be seen in today’s cutting-edge chemistry, materials science, and biology techniques. Each section of the book closes with an outline of the prospects for future developments. In the course of a career spanning more than 50 years, Goddard’s seminal work has led to dramatic advances in a diverse range of science and engineering fields. Presenting scientific essays and reflections by students, postdoctoral as...
This book summarizes the current state of knowledge regarding antibiotics and antibiotics resistance genes (ARGs) in the soil environment. It covers a wide range of topics to help readers understand antibiotics and ARGs in soils, the risks they pose for the environment, and options for effective control. In addition, it presents a range of essential tools and methodologies that can be used to address antibiotics and ARGs in a consistent, efficient, and cost-effective manner. Gathering contributions by international experts, the book addresses both theoretical aspects and practical applications.The topics discussed include antibiotics-producing microorganisms; the routes of entry and fate of ...
To understand safe water and sanitation in East Africa, it is important to consider the contributions of African feminist analysis. This perspective will unveil inequities in the distribution of resources, demonstrate how localized solutions which are driven by women’s collaborative work have had an impact by temporarily easing the burden, and paint a multilayered picture of the lives of women and girls who are the predominant providers of water to households. This book explores the effects of water and sanitation quality and availability on early childhood morbidity in East Africa from an African feminist sociological perspective. It presents a framework that considers the ways that the d...