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Life Of Professor Robert Hugh Pritchard, The: The Rise Of Genetics At Leicester
Colleagues and former students of the late Professor Pritchard (aka Bob), an eminent UK geneticist, have gathered memories about his scientific and personal life. Bob's early, crucial contributions to decipher gene structure and mechanism of recombination in fungi, and those in bacterial physiology and the cell cycle, are briefly summarized. Bob was appointed as a young professor (34 years old) to open a new Department of Genetics at the University of Leicester, a department that thrived under his leadership to become internationally recognized for the quality of its scientific research and teaching. Pritchard's research studies on Microbial Genetics and Physiology and his intellectual leade...
RNA Editing
The information encoded in DNA is conveyed to the rest of the cell in a molecule called RNA. To diversify this information, as well as repair it when mistakes are made, RNA is modified through a series of reactions known as RNA editing. This book describes the fascinating and unexpectedly diverse ways RNA editing can occur, in organisms ranging from single- celled protozoa to man.
Plant Signal Transduction
Plant growth and development is controlled by environmental cues (e.g. light, salinity) that are sensed by the plant via a variety of signal transduction pathways. This book gives an up-to-date summary of the large amount of information that is now available on the processes involved in the communication of plants with their environment.
Development
As a result of the molecular genetic analysis of development similar mechanisms for the regulation of gene expression are found in a wide range of organisms. In "Development - the Molecular Genetic Approach" these common mechanisms as well as the specific events leading to a differentiated cell are described. Particular items treated are, for example, how asymmetry is achieved, how cell size is determined, how cell division is controlled, how cell lineage influences development, how cells know their position, and how cells communicate during development.
Patterning in Vertebrate Development
'Patterning in Vertebrate Development' is a new volume in the 'Frontiers in Molecular Biology' series which provides a range of comprehensive, and authoritative reviews of current research into patterning, a fundamental process in developmental biology.
Cell Adhesion
Cell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure and function of the seven major classes of cell adhesion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. The roles of these cell adhesion proteins in important processes such as cell mediated immunity, development and disease are discussed. In the second section, the molecular orga...
Apoptosis
The number of cells within the human body is very tightly regulated: too many and we can develop cancer, too few and we may lose cells that we cannot replace. The number of cells is controlled by several different mechanisms in different tissues, but all are triggered to commit suicide should too many be in one place at one time, or become damaged. This book examines how this process of cell suicide (apoptosis) is regulated, and how our understanding of this process may lead to novel treatments for a wide variety of human diseases.
Chromatin Structure and Gene Expression
Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.
Molecular Tinkering
Reveals some of the thrilling developments that have transformed biology since the 1960s. Highlights the challenges ahead for biologists but suggests what they can learn from the past. Energetic, jargon-free writing that will appeal to a broad audience. During the 1960s Edinburgh became a hotbed for a forward-thinking group of biologists. This is the story of these innovators who saw that life’s big mysteries were best tackled by studying its molecular foundations. It introduces the eccentric thinkers, ingenious tinkerers and tenacious experimenters who broke down the cultural barriers between traditional scientific disciplines. They produced a series of transformative ideas and tools that...
Molecular Chaperones in the Cell
In this text, leading experts synthesise our body of knowledge , and the reader gains not only a fuller understanding of the roles of chaperones in the context of cellular processes, but also an insight into the nature of these proteins.
