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Brain Receptor Methodologies, Part A, General Methods and Concepts: Amines and Acetylcholine provides information pertinent to neurotransmitter and neuromodulator receptors in brain. This book explores the methodologies that can used to address several basic and clinical problems. Organized into two sections encompassing 18 chapters, this book starts with an overview of the receptor concept, which can be validated from indirect evidence obtained in studies of the quantitative aspects of drug antagonism. This text then examines the radioligand–receptor binding interactions. Other chapters consider immunocytochemistry, which has a primary role in determining the precise distribution of regulatory peptides to neural and endocrine elements of the diffuse neuroendocrine system. The final chapter discusses the use of the radioligand binding procedure for the study of muscarinic receptors, which has expanded the area of muscarinic receptor pharmacology. Biochemists, pharmacologists, physiologists, and researchers engaged in the fields of neurobiology and neuroscience will find this book extremely useful.
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Understanding the treacherous currents of Pakistani politics
A complete explanation of the U.S. decision to go to war in 2003.
Praise for the Series:"The mainly sharp scientific focus of this set of snapshots is a credit to both the contricutors and the editorial team."--Biotechnology and Applied Biochemistry Techniques in Protein Chemistry VIII is the latest volume in this successful series. As a valuable bench-top reference tool for protein chemists, the ten section sof the book are divided by subject area to show the reader which techniques are currently applied to particular problems in protein science. This approach reflects current trends in which specific instruments and methodologies are used in several different areas.* * The book features the latest advances in protein chemistry methodologies in the following areas:* Protein sequencing and amino acid analysis* Mass spectral analysis of peptides and proteins* Posttranslational processing* High-sensitivity protein and peptide separations* Protein folding and NMR* Functional domain analysis* Protein design and engineering* Three-dimensional protein structure
In March 2004, Capt. Jason Whiteley was appointed the governance officer for Al Dora, one of Baghdad's most violent districts. His job was to establish and oversee a council structure for Iraqis that would allow them to begin governing themselves.The nature of persuading Iraqis to support the coalition quickly progressed from simply granting them privileges to ignore curfews to a more complex relationship defined by illicit dealing, preferential treatment, and a vicious cycle of assassination attempts. In these streets of Al Dora,Whiteley was feared and loved as the man they called Abu Floos—or “Father of Money.” Father of Money is the story of Captain Whiteley's journey into a moral m...
One of the major advances in the understanding of the mechanism of action of hormones, neurotransmitters and drugs had arisen from the hypothesis that the physiological or pharmacological responses are trig gered by their interaction with specific cell compo nents, termed receptors. However, the presence of receptors has been inferred from indirect data, and only recently has it been possible to study the kinetics of the interaction between drug and receptors directly, through the so called "binding technique. " This NATO-ASI on "Principles and Methods in Receptor Binding" was devoted mainly to the following aspects of the study of receptors: the principles underlying the use of the binding ...
Features interviews with many of Aung San Suu Kyi's closest associates, as well as one with Suu Kyi herself in February 2011, just three months after her release from house arrest; Explores Burma's history as well as the personal and political struggles of its best-known human rights activist; Puts Suu Kyi's fight for democracy in an authoritarian regime in global and historical perspective