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Peter Vogt
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Oncogenes and Retroviruses
The newest volume in the Current Topics in Microbiology and Immunology series edited by Dr. Vogt and dealing with oncogenes and retroviruses contains four review articles by international authorities in the field. These articles presenting the latest research results continue the tradition of excellence for which the series is so well known.
Retroviruses 1
1. 1 Scope of the Review This review was intended initially as a reference source for those interested in the origins and fITst descriptions ofthe defective avian sarcoma viruses. Quite a few of these viruses have been characterized in the past few years and their varied nomenclature according to source, discoverer, date of isolation or biological properties could result in some con fusion among those attempting to follow the literature. Information will be included on the molecular biology of the sarcoma viruses, rather more of which is available than when the review was fITst conceived, although in this respect the review will inevitably be out of date by the time of publication. If any bi...
Current Topics in Microbiology and Immunology
Several discoveries are noteworthy for allowing us to probe the recesses of the virus infected cell and to search for cryptic viral genomes which might provide clues in our studies of cancer etiology or developmental biology. One of the most notable was the dis covery of reverse transcriptase. This marked a momentous occasion in the history of molecular biology. Not only did it provide insight into the mechanism of persistence of retroviruses but it also provided us with an enzyme that could synthesize a DNA copy of any RNA. This DNA copy could then be used as a hybridization reagent to search for both complementary DNA and viral-specific RNA. Thus one could follow the course of any viral in...
Retroviruses 2
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Retroviruses 4
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Retroviruses
This book gives a synthesis of current knowledge on ret- rovirology. Each chapter deals with a different step in the virus life cycle, detailing the molecular aspects of virus replication. The comparison of different retroviruses exemplifies variations. Specific topics include the evolution of retrovirus genomes, integration of the provirus, viral DNA transcriptional and translational control of viral gene expression, processing of viral proteins, and packaging of virion RNA. Data on HIV and HTLV-1 are covered as well as research on animal retrovirus sys- tems.
Satellites and Defective Viral RNAs
The nine chapters presented in this book provide contemporary reviews of research on defective RNAs, satellite RNA viruses, and dependent RNA viruses that require the presence of a helper virus in order to establish productive infections. Since their initial identification nearly four decades ago, fundamental analyses of pathogenic and interdependent interactions involving these agents have contributed enormously to our appreciation of virus structure, RNA replication, and processes leading to disease. Findings arising from these studies have also advanced numerous ancillary areas, including structure and function of nucleic acids and proteins, nucleoprotein interactions, translational mecha...
Retroviruses 3
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