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Biomarkers of Alzheimer's Disease: The Present and the Future
Alzheimer disease (AD) is a neurodegenerative disorder characterized by significant cognitive deficits, behavioral changes, sleep disorders and loss of functional autonomy. AD represents the main cause of dementia and has become a major public health issue. In addition, the number of patients suffering from AD is growing rapidly as the population ages worldwide. Memory impairment is usually the earliest clinical and core symptom of this disease. The diagnosis at a late clinical stage is relatively easy. However, a delay in the diagnosis is damageable for the handling of patients in terms of optimal medical and social care. The actual interest of the scientific head-ways is to optimize the di...
New Directions in the Ethics of Assisted Suicide and Euthanasia
This book provides novel perspectives on ethical justifiability of assisted dying in the revised edition of New Directions in the Ethics of Assisted Suicide and Euthanasia. Going significantly beyond traditional debates about the value of human life, the ethical significance of individual autonomy, the compatibility of assisted dying with the ethical obligations of medical professionals, and questions surrounding intention and causation, this book promises to shift the terrain of the ethical debates about assisted dying. The novel themes discussed in the revised edition include the role of markets, disability, gender, artificial intelligence, medical futility, race, and transhumanism. Ideal for advanced courses in bioethics and healthcare ethics, the book illustrates how social and technological developments will shape debates about assisted dying in the years to come.
Immunomodulatory Roles of Tryptophan Metabolites in Inflammation and Cancer
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Neuropsychiatric Disorders and Epigenetics
Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmenta...
Neurogenic Language Disorders in Children
Language disorders in children are one of the most frequent causes of difficulties in communication, social interaction, learning and academic achievement. It has been estimated that over 5% of children present with some kind of language disorder. This volume illustrates the state of the art in neurogenic language disorders in children. The most recent findings about acquired epileptiform aphasias (from Landau-Kleffner syndrome to autistic regression) are presented and discussed.Language disorders in children with early brain lesions are reviewed in relation to the side of the lesion and their epileptic correlates (e.g., paroxysmal abnormalities during NREM sleep). New clinical reports are p...
Guanidines 2
Guanidine is named for its similarity to the purine guanine which, in turn, is named for its principal source guano, which comes from the Inca word, huano, for dung. Guanidine, therefore, translates into dung-like, which is hardly a genteel way to introduce a subject. On the other hand, texts are seldom inspirational, "frequently crude and rarely literary and should be judged on how successfully they assemble, organize and present current data. I am impressed that the material which fol]ows goes a long way toward successfully achieving those goals. Tue International Guanidine Society is a synthesis of three groups of investigators: biologists studying guanidines as phosphagens, neurologists ...
Ethics and Poetics
Bringing together international scholars interested in the ethics of fiction, this book extends the rich field of ethical literary criticism that has emerged in the last twenty years. New ground is broached in that the authors explore literariness itself as constitutive of ethical intimations about the pluralistic community and about egalitarian modes of communication. The epistemological point of departure is the ethical thought of modernity as filtered through Hegelian recognition as infinite social responsibility. The structure of the anthology reflects this anchoring as the authors investigate modalities of recognition and social regeneration via literary language, which effects the tran...
A Companion to Paleoanthropology
A Companion to Paleoanthropology presents a compendium of readings from leading scholars in the field that define our current knowledge of the major discoveries and developments in human origins and human evolution, tracing the fossil record from primate and hominid origins to the dispersal of modern humans across the globe. Represents an accessible state-of-the-art summary of the entire field of paleoanthropology, with an overview of hominid taxonomy Features articles on the key discoveries in ape and human evolution, in cranial, postcranial and brain evolution, growth and development Surveys the breadth of the paleontological record from primate origins to modern humans Highlights the unique methods and techniques of paleoanthropology, including dating and ecological methods, and use of living primate date to reconstruct behavior in fossil apes and humans
