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Cardiovascular and Metabolic Disease
Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book brings together the recent information on these disorders and the links that exist between them in order to provide a complete picture of drug discovery for these conditions. The main three sections comprehensively discuss obesity, hypertension and cardiovascular disease, and diabetes in turn, following an introduction to the molecular links between them. The final chapter provides perspectives on future directions of the field. Chapters are contributed by leaders in the field from academia and industry and cover biomark...
Customer-Centric Project Management
There has been a sea-change in the focus of organizations - whether private or public - away from a traditional product- or service-centricity towards customer-centricity and projects are just as much a part of that change. Projects must deliver value; projects must involve stakeholders, and Elizabeth Harrin and Phil Peplow demonstrate convincingly that stakeholders are the ones who get to decide what ’value’ actually means. Customer-Centric Project Management is a short guide explaining what customer-centricity means in terms of how you work and its importance for project performance; using tools and processes to guide customer-centric thinking will help you see the results of engagemen...
MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets
From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.
Hill of Squandered Valour
“Good focused context” pinpoints the historical significance of the single bloodiest episode in the Second Boer War—from a Zulu warfare expert (FGS Forum). Spion Kop, just northeast of Ladysmith, South Africa, was the largest hill in the region, being over 1,400 feet high, and it lay almost exactly at the center of the Boer line. If the British could capture this position and bring artillery to the hill, they would then command the flanks of the surrounding Boer positions. On the night of January 23, 1900, a large British force under Maj. Gen. Edward Woodgate was dispatched to secure the height, with Lt. Col. Alexander Thorneycroft selected to lead the initial assault. However, the Boe...
MicroRNAs in Diseases and Disorders
From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.
Neurodegenerative Diseases Biomarkers
This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.
The Constable Twitten Mysteries
DISCOVER THE AWARD-WINNING MURDER MYSTERY SERIES FROM SUNDAY TIMES BESTSELLING AUTHOR, PERFECT FOR FANS OF RICHARD OSMAN 'Funny, clever, charming, imaginative and nostalgic' The Times 'Terrific' Mail on Sunday 'A giddy spell of sheer delight' Daily Mail This digital bundle includes all 4 books in Lynne Truss's gloriously funny crime series set in 1950s Brighton: A Shot in the Dark Winner of the Crimefest Last Laugh Award Inspector Steine rather enjoys his life as a policeman by the sea. No criminals, no crime, no stress. So it's really rather annoying when an ambitious – not to mention irritating – new constable shows up to work and starts investigating a spate of burglaries. Could it be...
