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The Creation of Psychopharmacology
David Healy follows his widely praised study, The Antidepressant Era, with an even more ambitious and dramatic story: the discovery and development of antipsychotic medication. Healy argues that the discovery of chlorpromazine (more generally known as Thorazine) is as significant in the history of medicine as the discovery of penicillin, reminding readers of the worldwide prevalence of insanity within living memory. But Healy tells not of the triumph of science but of a stream of fruitful accidents, of technological discovery leading neuroscientific research, of fierce professional competition and the backlash of the antipsychiatry movement of the 1960s. A chemical treatment was developed fo...
Imaging of the Human Brain in Health and Disease
Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's dis...
The Dopamine Receptors
As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.
Partnership for Excellence
The University of Toronto’s Faculty of Medicine is North America’s largest medical school and a major health consortium, boasting nine affiliated teaching hospitals and a network of research institutes. It is where insulin was pioneered, stem cells were first discovered, and famous physicians from Vincent Lam to Sheela Basrur began their careers. But despite all its major accomplishments, the faculty’s impressive history has never before been comprehensively documented. In Partnership for Excellence, senior medical historian and award-winning author Edward Shorter details the Faculty of Medicine’s history from its inception as a small provincial school to its present day status as an international powerhouse. Deeply researched through front-line interviews and primary sources, it ties the story of the faculty and its teaching hospitals to the general history of medicine over this period. Shorter emphasizes the enormous concentration of intellectual energy in the faculty that has allowed it to become the dominant force in Canadian medicine, home to a legion of medical pioneers and achievements.
Biological Horizons in Surface Science
Biological Horizons in Surface Science presents techniques used in surface science research as well as experimental data. It is organized in such a way that there is a transition from the more theoretical or molecular to the more biological. Emphasis is placed on the importance of water in determining molecular architecture and interactions. Methods of examining molecular associations and complex formation of molecules are discussed, and the results from such studies are reviewed. Permeability is examined from the point of view of the energies required to penetrate between two different phases, and from the role that multicellular membranes may play in directing the diffusion of ions or solu...
Blaming the Brain
In Blaming the Brain Elliott Valenstein exposes the many weaknesses inherent in the scientific arguments supporting the widely accepted theory that biochemical imbalances are the main cause of mental illness. He lays bare the commercial motives of drug companies and their huge stake in expanding their markets. This provocative book will force patients, practitioners, and prescribers alike to rethink the causes of mental illness and the methods by which we treat it.
Schizophrenia
Written by a medical writer and family member of someone suffering from schizophrenia, this book outlines all of the issues involved with schizophrenia and its treatment including stigma, history, causes, physiological changes in the brain, and best treatments. It is an ideal reference and support for family members and others interested in this disease. It is also suitable as supplementary reading for students in health care fields (including medicine and nursing), psychology, social work and any occupation that needs solid information about schizophrenia. The book is recommended by the World Fellowship for Schizophrenia and Allied Disorders on its website.
Brain Receptor Methodologies Pt A
Brain Receptor Methodologies, Part A, General Methods and Concepts: Amines and Acetylcholine provides information pertinent to neurotransmitter and neuromodulator receptors in brain. This book explores the methodologies that can used to address several basic and clinical problems. Organized into two sections encompassing 18 chapters, this book starts with an overview of the receptor concept, which can be validated from indirect evidence obtained in studies of the quantitative aspects of drug antagonism. This text then examines the radioligand–receptor binding interactions. Other chapters consider immunocytochemistry, which has a primary role in determining the precise distribution of regulatory peptides to neural and endocrine elements of the diffuse neuroendocrine system. The final chapter discusses the use of the radioligand binding procedure for the study of muscarinic receptors, which has expanded the area of muscarinic receptor pharmacology. Biochemists, pharmacologists, physiologists, and researchers engaged in the fields of neurobiology and neuroscience will find this book extremely useful.
Malady of the Mind
"This brilliant portait of schizophrenia-the most malignant and least understood mental illness-by renowned psychiatrist Jeffrey Lieberman, Chair of Columbia's legendary Psychiatry department, interweaves cultural and scientific history with dramatic patient portraits and clinical experiences to impart a revolutionary message of hope: that for the first time in human history, schizophrenia can not just be effectively treated, but even prevented. Of the many myths and misconceptions that have historically obscured our understanding of schizophrenia, the most pernicious is that there is no effective treatment or cure. The reality couldn't be more different: the truth is that today's treatments...
