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Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder caused by autoantibodies against post-synaptic proteins at the neuromuscular junction. These antibodies mostly attack the acetylcholine receptor (AChR), the muscle-specific kinase (MuSK), and the low-density lipoprotein-related protein 4 (LRP4). The main clinical characteristic of the disease is the presence of fluctuating fatigable muscle weakness involving the extraocular, facial, bulbar, respiratory, cervical, and proximal limb muscles. It is known that the thymus has an important role in the pathophysiology of the disease, and some patients associate a thymoma.
Throughout his writing career, and especially in the last thirty years of his life, Aldous Huxley exhibited a deep interest in human potentialities, which he often described as our greatest unused natural resource. The present volume is the first book to focus on this Huxleyan core concern. It is based on presentations given at the Sixth International Aldous Huxley Symposium held in 2017 at the University of Almería (Spain). This volume collects essays by eleven scholars from eight countries that discuss Huxley's concept of human potentialities from an interdisciplinary perspective. This is another innovative feature of this book, since today Huxley is mainly remembered as a novelist, altho...
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people glob...
Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for...
Transition from Student Nurse to Registered Nurse is a book developed to help budding nurses navigate our complex healthcare system with greater ease. Graduating nurses are faced with many challenges—seemingly contradictory nursing practices, rotating shifts, confusing referral systems, and stressful nursing key performance indicators. The reader will have a good overview of the healthcare system. It also tells you how patients are placed in different disciplines and how different services are provided. More importantly, it discusses the core skills of a Registered Nurse, such as vital signs interpretation, management of commonly seen medical emergencies and conditions, wound management, and even dealing with non-medical issues. But that’s not all. Readers will have insights into the various professions that a Registered Nurse works with. Written in collaboration with Medical and Allied Health professionals, this book will definitely give you knowledge and perspectives that no other books can offer. Whether you are a nursing student, fresh nursing graduate, or a seasoned nurse, this is the book to have!
A no-nonsense guide to finding your unique fitness program Have you struggled to stick with a nutrition or training plan long enough to see your desired results? Or perhaps you’ve devoted time and effort to your training but are frustrated because you’re not seeing the tangible changes you really want. If either scenario sounds familiar, then Find Your Stride is for you. In it, avid runner and fitness writer Emily Rudow explains why there’s no universal formula for fitness success—how trying to stick to a rigid plan, with no flexibility for individual needs, causes us to veer off our well-intentioned paths. Emily combines the latest research on nutrition, exercise science, and psycho...
In recent decades there have been several constructivist scholars who have looked at how norms change in international relations. However few have taken a closer look at the particular strategies that are employed to further change, or looked at the common factors that have been in play in these processes. This book seeks to further the debates by looking at both agency and structure in tandem. It focuses on the practices of linked ecologies (formal or informal alliances), undertaken by individuals who are the constitutive parts of norm change processes and who have moved between international organizations, academic institutions, think tanks, NGOs and member states. The book sheds new light...
Prior to 1862, when the Department of Agriculture was established, the report on agriculture was prepared and published by the Commissioner of Patents, and forms volume or part of volume, of his annual reports, the first being that of 1840. Cf. Checklist of public documents ... Washington, 1895, p. 148.