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Heme Oxygenase
Heme oxygenase is an enzyme which breaks down heme, the iron-containing oxygen-carrying constituent of the red blood cells. Heme must be synthesised and degraded within an individual nucleated cell, as heme is essential for the maintenance of cellular homeostasis by sensing or using oxygen. Physiological heme degradation is catalysed by the two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding CO, iron, and biliverdin IX N. Heme oxygenase-1 (HO-1), has potent anti-inflammatory, anti-oxidant and anti-proliferative effects, is up-regulated by multiple stimuli and provides protection against oxidative stress. HO-1 also plays an important role in the regulation of cardiovascular function and is involved in many other diseases such as sickle cell disease. This new book brings together leading research from around the world in this field.
The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity and cytoprotection
Degradation of heme involves its conversion to biliverdin by heme oxygenase followed by reduction of biliverdin to bilirubin by biliverdin reductase. There is ample evidence for the pleiotropic functions of biliverdin reductase in cell signaling and regulation of gene expression. This enzyme plays a major role in glucose uptake and the stress response. Bilirubin has been shown to behave as a "double-edged sword". It can exert either cytotoxic or cytoprotective effects, depending on the blood and/or tissue concentration of its free fraction, the nature of the target cell or tissue, and the cellular redox state. Its antioxidant effect is the basis for the proposed cardioprotective effect of relatively low blood concentrations of bilirubin in humans with moderate hyperbilirubinemia. This Special Topic forum is intended to serve as a platform for updating information and presenting advances in basic and clinical research in the above and related subjects.
Imaging of the Newborn
This fully revised new edition of a popular practical guide provides a concise introduction to radiology in neonates, covering the full range of problems likely to be encountered in the neonatal ICU. The material is presented in atlas format, with concise text descriptions to provide a quick overview of the indications, utility, appearances and interpretation of images of common neonatal pathology. Numerous high-quality images enable easy 'matching' with clinical cases faced by the reader. New to this edition: • Images updated throughout to reflect improvements in equipment and scanning techniques • Expanded chapters on cardiovascular problems, bone and prenatal ultrasound • New chapters on clinical utility of procedures, metabolic and inborn errors of metabolism, and antenatal diagnosis of common abnormalities Concise and practical, this is an essential training resource for all those who work in the neonatal ICU, including pediatric residents and trainees, junior radiologists and nurse practitioners.
The Vanishing Vision
This spirited history of public television offers an insider's account of its topsy-turvy forty-year odyssey. James Day, a founder of San Francisco's KQED and a past president of New York's WNET, provides a vivid and often amusing behind-the-screens history. Day tells how a program producer, desperate to locate a family willing to live with television cameras for seven months, borrowed a dime—and a suggestion—from a blind date and telephoned the Louds of Santa Barbara. The result was the mesmerizing twelve-hour documentary An American Family. Day relates how Big Bird and his friends were created to spice up Sesame Street when test runs showed a flagging interest in the program's "live-ac...
Etouffee, Mon Amour
This luxurious photography book on New Orleans restaurants celebrates the city's love affair with food. From the legendary Tujague's to the down-home Uglesich's, these beloved establishments are shown off in all their glory for residents and visitors alike. From the antebellum legacies of grand old restaurants like Antoine's, Commander's Palace, and Bruning's to the newcomers like Jacques-Imo's, Bayona, and Clancy's, not to mention the legion in between, the countless stories of establishments dedicated to the je ne sais quoi of dining form part of the essential history of New Orleans. This rich mix of history and evocative photographs documents an unparalleled majesty of the senses, a decad...
Recovering a Public Vision for Public Television
In 1995, US public television faced possible elimination of federal funding, potentially commercialising this type of broadcasting. This study suggests that these strains have undermined public broadcasting historically; the result is that programming no longer prioritises social reform.
The CTSA Program at NIH
In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the cou...
Getting Off at Elysian Fields
No city in America knows how to mark death with more funerary panache than New Orleans. The pageants commemorating departed citizens are often in themselves works of performance art. A grand obituary remains key to this Stygian passage. And no one writes them like New Orleanian John Pope. Collected here are not just simple, mindless recitations of schools and workplaces, marriages, and mourners bereft. These pieces in Getting Off at Elysian Fields: Obituaries from the New Orleans “Times-Picayune” are full-blooded life stories with accounts of great achievements, dubious dabblings, unavoidable foibles, relationships gone sour, and happenstances that turn out to be life-changing. To be sur...
