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Drug therapy of migraine and other headaches underwent a dramatic change in the last 10 years. This book is an overview of the drugs in the treatment of acute headache attacks and their prophylaxis. Each chapter is written by a top expert, in most cases the principal investigator of large clinical trials, and a review on the pharmacology of each substance is provided. Treatment recommendations rely on evidence-based data and are put into a clinical context. Chapters cover all the new 'triptans' but also more traditional drugs such as analgesics, opioids and ergots. The list of authors is the who's who of modern headache research and practice. Physicians treating patients with headaches and pharmacologists interested in headache drugs will benefit most from this up-to-date critical overview.
A collection of reviews on selected areas of synaptic transmission from neuroscientists in a number of areas of work in the nervous system and related disciplines. Five areas are covered - long-term potentiation, galanin, autonomic, opioids and 5-hydroxytryptamine.
Migraine treatment improved considerably with the advent of the 'triptans' in the 1990s. While the drugs used previously for headache treatment had efficacy, some compounds had bothersome side effects and their overuse could lead to severe complications. In the early days of the triptans, it was widely presumed that migraine was no longer a treatment problem. However, it has gradually been recognized that a significant proportion of patients are not responsive to triptans or do not tolerate them. It is now clear that, even with effective treatment, patients with frequent migraine attacks are not treated well exclusively with acute medications. This is partly because patients are still bother...
Established worldwide as the one definitive, encyclopedic reference on headache, The Headaches is now in its thoroughly revised, updated Third Edition. The foremost international authorities examine the mechanisms of over 100 types of headache and provide evidence-based treatment recommendations, including extensive tables of controlled clinical trials. This edition presents the revised International Headache Society classification of headaches and explains how to use this new classification for accurate diagnosis. Many headache entities are discussed for the first time, such as chronic migraines; primary headache attributed to sexual activity; primary stabbing, cough, exertional, and thunderclap headaches; hypnic headaches; and new daily persistent headaches. A new section focuses on childhood headaches. Chapters that focus on headaches in elderly patients and patients with psychiatric or medical diseases are also included.
'In many respects this is an outstanding book. It provides an invaluable source of published evidence for the treatment of patients with headache.'