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Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.
This book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last...
This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.
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Study on a form of bonded labor system in Nepal.
Die rasante wirtschaftliche Entwicklung Indiens wird häufig mit dem Erwachen eines schlafenden Elefanten verglichen. Ein Engagement in Indien muss jedoch sorgfältig geprüft werden. So stellen die mangelhafte Infrastruktur, Bürokratie, restriktive Gesetzgebung, Korruption und interkulturelle Managementkonflikte eine Herausforderung für ausländische Unternehmungen dar. In diesem Buch werden die Bedingungen für ausländische Unternehmungen in Indien anhand zahlreicher Praxisbeispiele dargestellt und konkrete Entscheidungshilfen für Markteintritt und Marktbearbeitung, die Gestaltung von Organisation und Personalmanagement sowie zur Beziehung zu staatlichen Institutionen und privaten Interessengruppen gegeben. Abgerundet werden diese Aspekte durch Fallstudien sowie einen umfangreichen Adressteil. Das Buch basiert auf langjähriger Beratung und Untersuchung deutscher Unternehmungen.
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The book covers 75 autopsy-based cases (about 75) of common and uncommon presentations of various cardiovascular diseases (CVDs). It emphasizes the importance of the autopsies, which have played a pivotal role in the understanding of the pathology and hence the clinical manifestations of several CVDs. The book attempts to present the material from the perspective of the autopsy table. It uses the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition with final clinico-pathological correlation. Each case covers a complete journey of the deceased patient concisely under the following headings—title, clinical history, autopsy findings and discussion, which includes a brief review of the literature. The text is accompanied by relevant high-quality macroscopic and microscopic images. The book is relevant for specialists in pathology, cardiology, cardiac surgery, internal medicine, critical care and pediatrics
“कल्पना के परे” पुस्तक एक कला दस्तावेज कॉफी टेबल बुक है। इस कॉफ़ी टेबल बुक में डॉ. राकेश कुमार मौर्य की कला सफर और उनके जीवनकाल की साधना को दर्शाया गया है। कुदरत की रचाई हुई एक छोटी सी रचना को दिव्य ऊर्जा मिलते ही धीरे धीरे बड़े स्रोत में रूपांतरित होती है। जैसे कि कोई एक ...