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Substance Use Disorder (SUD) is a mental disorder that causes an individual to compulsively consume legal or illegal drugs such as alcohol, opioids, methamphetamine, marijuana, and medications, despite harmful consequences. According to the World Health Organization (WHO), alcohol causes 5.1 % of the global burden of disease, and harmful drinking behavior is associated with more than 200 diseases and injury conditions. According to the UN Office on Drugs and Crime, about 200 million people are addicted to cocaine, cannabis, opioids and sedative-hypnotics.
The book is a collection of high-quality peer-reviewed research papers presented in International Conference on Soft Computing Systems (ICSCS 2015) held at Noorul Islam Centre for Higher Education, Chennai, India. These research papers provide the latest developments in the emerging areas of Soft Computing in Engineering and Technology. The book is organized in two volumes and discusses a wide variety of industrial, engineering and scientific applications of the emerging techniques. It presents invited papers from the inventors/originators of new applications and advanced technologies.
Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level. These changes drive normal cells to proliferate and escape processes that usually regulate their survival and migration. Many of these alterations are often associated with signaling pathways which regulate cell growth and division, cell death, survival, invasion and metastasis, and angiogenesis. Almost all cancer cells show high expression of signaling components including growth factor receptor tyrosine kinases (RTKs), small GTPases, serine/threonine kinases, cytoplasmic tyrosine kinases, lipid kinases, estrogen receptor, activation of transcription factors Myc and NF-κB, etc. Updated knowledge ab...
This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS
This Book is a digital edition of Print Edition of Lions District 324A6 Directory for the year 2014-15. It is released by District Governor MJF Lion D Thulasingam. The Directory is on 7000+ members of the District and is printed in 900 pages using 3kg of paper (for each book). Usage of this Digital Edition enables lion to refer the same directory from their Tablets, Mobile Phones, IPads etc, thus enabling portability of information. In addition, reduced number of copies can be printed, thus saving paper and the Earth. The Print Edition is Edited by MJF Lion A T Ravichandran, Directory Committee Chairman and his Team. This Digital Book is Edited by Lion Dr Er J Shivakumaar.
Compensating for cytotoxicity in the multicellular organism by a certain level of cellular proliferation is the primary aim of homeostasis. In addition, the loss of cellular proliferation control (tumorigenesis) is at least as important as cytotoxicity, however, it is a contrasting trauma. With the disruption of the delicate balance between cytotoxicity and proliferation, confrontation with cancer can inevitably occur. This book presents important information pertaining to the molecular control of the mechanisms of cytotoxicity and cellular proliferation as they relate to cancer. It is designed for students and researchers studying cytotoxicity and its control.
Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interf...
This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients
Recent global cancer statistical data has clearly indicated that prostate cancer is currently the second most frequently diagnosed cancer (at 15% of all male cancers) and globally the sixth leading cause of cancer death in males. This book is a summary of prostate cancer, covering its incidence, epidemiology, and current treatment options. It also serves as an up-to-date review of the status of currently available alternative and complementary medicines for treating prostate cancer, including various plant extracts, herbal formulations, natural products, yoga, acupuncture, Ayurveda, homeopathy, and Siddha medicines used in prostate cancer therapy.
Lions Clubs International Celebrates Centennial Year in 2016-17. Lions District 324A1 released this Centennial Mini Directory of Lion Leaders and Members, Released by District Governor PMJF Lion Er T M Gunaraja. This Digital Edition enables viewing it in the Smart Phones, Tablets, IPads and Digital Devices.