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Prions in Humans and Animals
This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A detailed presentation of the impact of prion diseases in fields such as pharmaceutics, blood products, disinfection, surgical instruments and epidemiology concludes with a discussion of preventive measures. A renowned editorial...
Prions
Essential reading for everyone working with prions from the PhD student to the experienced scientist.
Prion Diseases
The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.
A Birdwatchers' Guide to Morocco
Morocco is a paradise for birdwatchers with its coasts, islands, wadis, plains, forests, mountains and deserts creating conditions that are often very different from those found in Europe. The richness of these habitats is clearly illustrated by the 452 species which have been recorded so far. Fifteen years have passed since the publication of the first edition of this book. This is a very short period in the dynamics of bird communities, but a very long period in a country that has developed so quickly. The Government is encouraging development and tourism, for example in the Atlantic West Sahara, which opens up great new sites for birdwatchers. The most important, and easily accessible of these new sites have been included in this second edition, and the original 15 sites have been increased to at least 50.
Prions and Diseases
Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
Human Prion Diseases
Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. - Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms - Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans - Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms
A Bit of a Stretch
'Shocking, scathing, entertaining.' Guardian 'Incredibly compelling.' The Times 'Heart-breaking.' Sunday Times Where can a tin of tuna buy you clean clothes? Where is it easier to get 'spice' than paracetamol? Where does self-harm barely raise an eyebrow? Welcome to Her Majesty's Prison Service. Like most people, documentary-maker Chris Atkins didn't spend much time thinking about prisons. But after becoming embroiled in a dodgy scheme to fund his latest film, he was sent down for five years. His new home would be HMP Wandsworth, one of the largest and most dysfunctional prisons in Europe. With a cast of characters ranging from wily drug dealers to senior officials bent on endless reform, this powerful memoir uncovers the horrifying reality behind the locked gates. Filled with dark humour and shocking stories, A Bit of a Stretch reveals why our creaking prison system is sorely costing us all - and why you should care.
The Prion Protein
A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected....
Punishment and Prisons
Joe Sim traces the development of penal strategy over the past three decades, through a critical analysis of the relationship between penal policy and state power. Exploring the contested histories of punishment that are prominent in criminology, and its development in penal policy, the book analyzes four key dimensions of modern penal trends continuity and discontinuity in penal policy and practice, reform and rehabilitation, contesting penal power, and abolitionism. Articulate, innovative, and theoretically informed, Punishment and Prisons offers a critical overview of contemporary penal politics that will prove a compelling addition to the criminological library.
