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Renaissance of Sickle Cell Disease Research in the Genome Era
The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder.Part 1 offers detailed revie...
Sickle Cell Disease and Hematopoietic Stem Cell Transplantation
This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.
Emerging Perspectives on Financial Well-Being
The pursuit of financial well-being has become an increasingly complex challenge for individuals and societies alike. The subjective nature of financial well-being, shaped by diverse aspirations, values, and external circumstances, underscores the need for a nuanced exploration of the factors influencing it. In this context, the book Emerging Perspectives on Financial Well-Being takes center stage as a beacon of understanding, delving into the multifaceted dimensions of financial wellness. Within the pages of this volume, the critical issues surrounding financial well-being are dissected, addressing the need for financial education, disciplined management, and goal setting amidst an ever-cha...
Benign Hematologic Disorders in Children, An Issue of Pediatric Clinics of North America
This issue will provide a current update on diagnosis, treatment, and management of children with being hematological disorders. Dr. Callaghan has put together a comprehensive issue with clinical reviews written by top experts in the field. Articles are devoted to the following topics: Hemophilia; Sickle cell acute chest; Sickle cell drugs; Sickle cell gene therapy; Sickle cell menses and pain; Pediatric DVT; Atypical HUS; von Willebrand Disease; Female bleeding; Functional platelet disorders; Hemolytic anemia; Advocacy in hematology; ITP; and Acquired aplastic anemia. Readers will come away with the current clinical information they need to improve clinical outcomes.
Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease, An Issue of Hematology/Oncology Clinics
This issue of Hematology/Oncology Clinics, guest edited by Dr. Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses on pathophysiology of hemoglobinopathies, therapeutic targets, and new approaches to correcting ineffective erythropoiesis and iron dysregulation. Articles in this issue include Polymerization and red cell membrane changes; Overview on reperfusion injury in the pathophysiology of SCD; Regulation of ineffective erythropoiesis in iron metabolism; Altering oxygen affinity; Cellular adhesion and the endothelium; Arginine therapy; Role of the hemostatic system on SCD pathophysiology and potential therapeutics; Adenosine signaling and novel therapies; New approaches to correcting ineffective erythropoiesis and iron dysregulation; New approaches to correcting ineffective erythropoiesis and iron dysregulation; Fetal hemoglobin induction; Gene therapy for hemoglobinopathies; and Oxidative injury and the role of antioxidant therapy.
Cooley's Anemia
"This volume presents manuscripts stemming from the 'Ninth Cooley's Anemia Symposium,' held October 21-24, 2009 at the New York Academy of Sciences, and sponsored by the Cooley's Anemia Foundation and the New York Academy of Sciences"--Contents p.
Subcellular Proteomics
This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
Wave Propagation in Complex Environments
The problem of wave propagation, such as elastic waves, acoustic waves, and electromagnetic waves, are commonly encountered in a wide range of areas, including civil engineering, mechanical engineering, wireless communication, remote sensing, meteorology, etc. In realistic scenarios, waves normally propagate in complex environments. Electromagnetic waves are transmitted through the medium with small particles that have significant scattering and absorbing effects. Sound waves radiated by underwater vehicles in shallow seas are reflected by the sea surface and seabed. Wave propagation in complex environments is often associated with multi-physics fields. Ultrasound waves propagation in porous media can generate heat, and elastic waves in piezoelectric materials induce electric fields. In addition, the physical mechanism of wave propagation in complex environments should be investigated across different scales. For example, to understand the interaction between light transmission and the matters in the surrounding medium, it is necessary to couple particle physics, electromagnetics, and geometric optics.
The Stress Effect
Reveals the powerful and undermining effects of stress on good decision making-and what leaders can do about it The ability to make sound and timely decisions is the mark of a good leader. But when leaders with otherwise strong track records suddenly begin making poor decisions-as seen in the recent corporate scandals that rocked the business world-the impact can be widespread. In The Stress Effect, leadership expert Henry L. Thompson argues that stress is often the real culprit behind this leadership failure: when leaders' stress levels become sufficiently elevated-whether in the boardroom or on the front line of a manufacturing process-their ability to effectively use their emotional intel...
Annual Report
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