Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Translational Animal Models in Drug Discovery and Development
Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but fa...
Document
None
Reservoir Compartmentalization
"Reservoir compartmentalization - the segregation of a petroleum accumulation into a number of individual fluid/pressure compartments - controls the volume of moveable oil or gas that might be connected to any given well drilled in a field, and consequently impacts 'booking' of reserves and operational profitability. This is a general feature of modern exploration and production portfolios, and has driven major developments in geoscience, engineering and related technology. Given that compartmentalization is a consequence of many factors, an integrated subsurface approach is required to better understand and predict compartmentalization behaviour, and to minimize the risk of it occurring unexpectedly. This volume reviews our current understanding and ability to model compartmentalization. It highlights the necessity for effective specialist discipline integration, and the value of learning from operational experience in: detection and monitoring of compartmentalization; stratigraphic and mixed-mode compartmentalization; and fault-dominated compartmentalization"--Page 4 of cover.
Anne Boleyn
The classic biography of the most engaging of Henry VIII's wives.
Advances in Quantitative Remote Sensing in China – In Memory of Prof. Xiaowen Li
Quantitative land remote sensing has recently advanced dramatically, particularly in China. It has been largely driven by vast governmental investment, the availability of a huge amount of Chinese satellite data, geospatial information requirements for addressing pressing environmental issues and other societal benefits. Many individuals have also fostered and made great contributions to its development, and Prof. Xiaowen Li was one of these leading figures. This book is published in memory of Prof. Li. The papers collected in this book cover topics from surface reflectance simulation, inversion algorithm and estimation of variables, to applications in optical, thermal, Lidar and microwave r...
Integrated Fault Seal Analysis
Faults commonly trap fluids such as hydrocarbons and water and therefore are of economic significance. During hydrocarbon field development, smaller faults can provide baffles and/or conduits to flow. There are relatively simple, well established workflows to carry out a fault seal analysis for siliciclastic rocks based primarily on clay content. There are, however, outstanding challenges related to other rock types, to calibrating fault seal models (with static and dynamic data) and to handling uncertainty. The variety of studies presented here demonstrate the types of data required and workflows followed in today’s environment in order to understand the uncertainties, risks and upsides associated with fault-related fluid flow. These studies span all parts of the hydrocarbon value chain from exploration to production but are also of relevance for other industries such as radioactive waste and CO2 containment.
Abney park cemetery
None
